5izc A 1.92 BS01 NAP A 1 K13 R14 I15 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 K178 P204 G205 S207 L208 K12 R13 I14 Y33 H34 N35 S36 D61 L62 N92 A93 S94 T116 L140 K159 P185 G186 S188 L189 R14 D161 Y174 K178 R13 D142 Y155 K159 1.5.1.33 0000166,0016491,0047040 O76290 28983525 301 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVGKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc A 1.92 BS02 6F4 A 1 S95 F97 C168 Y174 V206 L209 P210 S94 F96 C149 Y155 V187 L190 P191 R14 D161 Y174 K178 R13 D142 Y155 K159 1.5.1.33 0000166,0016491,0047040 -logKd/Ki=3.95, IC50=112uM O76290 28983525 302 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVGKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc B 1.92 BS01 NAP B 1 R14 I15 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 K178 P204 G205 S207 R13 I14 Y33 H34 N35 S36 D61 L62 N92 A93 S94 T115 L138 K157 P183 G184 S186 R14 D161 Y174 K178 R13 D140 Y153 K157 1.5.1.33 0000166,0016491,0047040 O76290 28983525 301 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVKTVETQVAELIGTNAIAPFLLTMSFAQRQNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc B 1.92 BS02 6F4 B 1 S95 F97 C168 Y174 S94 F96 C147 Y153 R14 D161 Y174 K178 R13 D140 Y153 K157 1.5.1.33 0000166,0016491,0047040 O76290 28983525 302 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVKTVETQVAELIGTNAIAPFLLTMSFAQRQNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc C 1.92 BS01 NAP C 1 R14 I15 H33 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 K178 G205 V206 S207 R14 I15 H33 Y34 H35 N36 S37 D62 L63 N93 A94 S95 T116 L140 K159 G186 V187 S188 R14 D161 Y174 K178 R14 D142 Y155 K159 1.5.1.33 0000166,0016491,0047040 O76290 28983525 301 MEAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc C 1.92 BS02 6F4 C 1 S95 F97 C168 Y174 V206 L209 P210 W221 S95 F97 C149 Y155 V187 L190 P191 W194 R14 D161 Y174 K178 R14 D142 Y155 K159 1.5.1.33 0000166,0016491,0047040 O76290 28983525 302 MEAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc D 1.92 BS01 NAP D 1 R14 I15 H35 N36 S37 D62 L63 N93 A94 S95 T126 L159 K178 P204 G205 S207 R13 I14 H34 N35 S36 D61 L62 N92 A93 S94 T115 L139 K158 P184 G185 S187 R14 D161 Y174 K178 R13 D141 Y154 K158 1.5.1.33 0000166,0016491,0047040 O76290 28983525 301 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA 5izc D 1.92 BS02 6F4 D 1 S95 F97 C168 Y174 V206 P210 M213 W221 S94 F96 C148 Y154 V186 P190 M193 W201 R14 D161 Y174 K178 R13 D141 Y154 K158 1.5.1.33 0000166,0016491,0047040 O76290 28983525 302 EAPAAVVTGAAKRIGRAIAVKLHQTGYRVVIHYHNSAEAAVSLADELNKERSNTAVVCQADLTNSNVLPASCEEIINSCFRAFGRCDVLVNNASAFYPTPLVKTVETQVAELIGTNAIAPFLLTMSFAQRQSNLSIVNLCDAMVDQPCMAFSLYNMGKHALVGLTQSAALELAPYGIRVNGVAPGVSLLPVAMGEEEKDKWRRKVPLGRREASAEQIADAVIFLVSGSAQYITGSIIKVDGGLSLVHA