5itz A 2.2 BS01 peptide D 0 H406 W407 H398 W399 3.6.5.- 0000226,0000278,0003924,0005200,0005525,0005737,0005829,0005856,0005874,0007017,0015630,0016787,0046872 P81947 27219064 373 ~ 385 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVD 5itz A 2.2 BS02 GTP A 1 Q11 A12 Q15 A99 N101 S140 G143 G144 T145 G146 S178 E183 N206 Y224 N228 Q11 A12 Q15 A91 N93 S132 G135 G136 T137 G138 S170 E175 N198 Y216 N220 3.6.5.- 0000226,0000278,0003924,0005200,0005525,0005737,0005829,0005856,0005874,0007017,0015630,0016787,0046872 P81947 27219064 501 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVD 5itz A 2.2 BS03 LOC B 1 A180 V181 A172 V173 3.6.5.- 0000226,0000278,0003924,0005200,0005525,0005737,0005829,0005856,0005874,0007017,0015630,0016787,0046872 P81947 27219064 502 MRECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMPDDSFNTFFSETGAGKHVPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIGKEIIDLVLDRIRKLADQCTGLQGFLVFHSFGGGTGSGFTSLLMERLSVDYGKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYDICRRNLDIERPTYTNLNRLISQIVSSITASLRFDGALNVDLTEFQTNLVPYPRIHFPLATYAPVISAEKAYHEQLSVAEITNACFEPANQMVKCDPRHGKYMACCLLYRGDVVPKDVNAAIATIKTKRSIQFVDWCPTGFKVGINYQPPTVVPGGDLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEGEFSEAREDMAALEKDYEEVGVD 5itz B 2.2 BS01 peptide D 0 Y108 H192 Q193 E196 G412 D414 E417 E420 S423 N424 D427 Y102 H186 Q187 E190 G392 D394 E397 E400 S403 N404 D407 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0007399,0015630,0046872,0046982,1902669 Q6B856 27219064 373 ~ 385 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNAKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATA 5itz B 2.2 BS02 GDP B 1 G10 Q11 C12 Q15 S140 G143 G144 T145 G146 S178 E183 N206 Y224 N228 G10 Q11 C12 Q15 S134 G137 G138 T139 G140 S172 E177 N200 Y218 N222 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0007399,0015630,0046872,0046982,1902669 Q6B856 27219064 501 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNAKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATA 5itz B 2.2 BS03 LOC B 1 C241 A250 K254 L255 N258 M259 A316 I318 N350 K352 C235 A244 K248 L249 N252 M253 A304 I306 N338 K340 ? 0000226,0000278,0003924,0005200,0005525,0005737,0005856,0005874,0007017,0007399,0015630,0046872,0046982,1902669 IC50=800nM, Ki=780nM Q6B856 27219064 502 MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNAKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATA