5ikv A 2.508 BS01 FLF A 1 V349 L352 S353 Y355 Y385 G526 A527 S530 V317 L320 S321 Y323 Y353 G494 A495 S498 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005788,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050727,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 IC50=16nM P35354 27226593 601 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVP 5ikv A 2.508 BS02 COH A 1 Q203 H207 F210 T212 N382 Y385 H386 H388 L391 V447 Q454 Q171 H175 F178 T180 N350 Y353 H354 H356 L359 V415 Q422 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005788,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050727,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 P35354 27226593 602 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVP 5ikv B 2.508 BS01 FLF B 1 V349 Y385 W387 G526 A527 S530 V317 Y353 W355 G494 A495 S498 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005788,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050727,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 IC50=16nM P35354 27226593 601 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVP 5ikv B 2.508 BS02 COH B 1 Q203 H207 F210 T212 Y385 H386 H388 L391 V447 Q171 H175 F178 T180 Y353 H354 H356 L359 V415 Q203 H207 L384 Y385 H388 G526 S530 Q171 H175 L352 Y353 H356 G494 S498 1.14.99.1 0001516,0001525,0004601,0004666,0005515,0005634,0005637,0005640,0005737,0005783,0005788,0005789,0005901,0006979,0007566,0007612,0007613,0008217,0008284,0008285,0009410,0009624,0009750,0010042,0010269,0010575,0016020,0016702,0019371,0019899,0020037,0030282,0031394,0031622,0031915,0032227,0032310,0032355,0032496,0032991,0033138,0033280,0034097,0034605,0034612,0035633,0042127,0042307,0042633,0042803,0043005,0043065,0043066,0043154,0045429,0045786,0045907,0045986,0045987,0046697,0046872,0048661,0050727,0050873,0051213,0051384,0051926,0051968,0070542,0071222,0071260,0071284,0071318,0071456,0071471,0071498,0071636,0090050,0090271,0090336,0090362,0098869,0150077,1902219,1905375,1990776 P35354 27226593 602 NPCCSHPCQNRGVCMSVGFDQYKCDCTRTGFYGENCSTPEFLTRIKLFLKPTPNTVHYILTHFKGFWNVVNNIPFLRNAIMSYVLTSRSHLIDSPPTYNADYGYKSWEAFSNLSYYTRALPPVPDDCPTPLGVKGKKQLPDSNEIVEKLLLRRKFIPDPQGSNMMFAFFAQHFTHQFFKTDHKRGPAFTNGLGHGVDLNHIYGETLARQRKLRLFKDGKMKYQIIDGEMYPPTVKDTQAEMIYPPQVPEHLRFAVGQEVFGLVPGLMMYATIWLREHNRVCDVLKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNKQFQYQNRIAAEFNTLYHWHPLLPDTFQIHDQKYNYQQFIYNNSILLEHGITQFVESFTRQIAGRVAGGRNVPPAVQKVSQASIDQSRQMKYQSFNEYRKRFMLKPYESFEELTGEKEMSAELEALYGDIDAVELYPALLVEKPRPDAIFGETMVEVGAPFSLKGLMGNVICSPAYWKPSTFGGEVGFQIINTASIQSLICNNVKGCPFTSFSVP