5i5x A 1.65 BS01 PMP A 1 R99 R192 K202 Y207 E237 T240 M241 N242 L266 G268 V269 V270 T313 R94 R185 K195 Y200 E230 T233 M234 N235 L259 G261 V262 V263 T306 K202 K195 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26938474 401 SSFKAADLQLEMTQKPHKKPGPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5i5x A 1.65 BS02 68C A 1 F30 F75 K79 Y141 V170 Y173 A314 F25 F70 K74 Y136 V165 Y168 A307 K202 K195 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=0.2uM -logKd/Ki=6.70, IC50=0.2uM IC50=200nM O15382 26938474 402 SSFKAADLQLEMTQKPHKKPGPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5i5x B 1.65 BS01 PMP B 1 R99 R192 K202 Y207 E237 T240 M241 N242 L266 G268 V269 V270 G312 T313 R98 R191 K201 Y206 E236 T239 M240 N241 L265 G267 V268 V269 G311 T312 K202 K201 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26938474 401 SHMASSSFKAADLQLEMTQKPHKKPGLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5i5x B 1.65 BS02 68C B 1 F30 F75 K79 Y141 Y173 A314 F29 F74 K78 Y140 Y172 A313 K202 K201 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=0.2uM -logKd/Ki=6.70, IC50=0.2uM IC50=200nM O15382 26938474 402 SHMASSSFKAADLQLEMTQKPHKKPGLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV