5i43 A 1.95 BS01 ZN A 1 H218 H222 H228 H112 H116 H122 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 A 1.95 BS02 ZN A 2 H168 D170 H183 H196 H62 D64 H77 H90 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 A 1.95 BS03 CA A 1 D158 G190 G192 D194 D52 G84 G86 D88 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 A 1.95 BS04 CA A 2 D124 E199 E201 D18 E93 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 A 1.95 BS05 CA A 3 D175 G176 G178 I180 D198 E201 D69 G70 G72 I74 D92 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 A 1.95 BS06 67M A 1 G178 G179 I180 A182 H183 L214 H218 Q219 H222 H228 P238 Y240 G72 G73 I74 A76 H77 L108 H112 Q113 H116 H122 P132 Y134 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=7.20, IC50=63nM P39900 27356908 306 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 B 1.95 BS01 67M B 1 I180 A182 H183 L214 H218 Q219 H222 H228 V235 F237 P238 T239 Y240 I76 A78 H79 L110 H114 Q115 H118 H124 V131 F133 P134 T135 Y136 H218 Q219 H222 H228 H114 Q115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 B 1.95 BS02 ZN B 1 H218 H222 H228 H114 H118 H124 H218 Q219 H222 H228 H114 Q115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 B 1.95 BS03 ZN B 2 H168 D170 H183 H196 H64 D66 H79 H92 H218 Q219 H222 H228 H114 Q115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 B 1.95 BS04 CA B 1 D158 G190 G192 D194 D54 G86 G88 D90 H218 Q219 H222 H228 H114 Q115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 B 1.95 BS05 CA B 2 D124 E199 E201 D20 E95 E97 H218 Q219 H222 H228 H114 Q115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 B 1.95 BS06 CA B 3 D175 G176 G178 I180 D198 E201 D71 G72 G74 I76 D94 E97 H218 Q219 H222 H228 H114 Q115 H118 H124 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 MGPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 C 1.95 BS01 67M C 1 G179 I180 A182 H183 L214 T215 H218 Q219 H222 H228 P238 Y240 G74 I75 A77 H78 L109 T110 H113 Q114 H117 H123 P133 Y135 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 C 1.95 BS02 ZN C 1 H218 H222 H228 H113 H117 H123 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 C 1.95 BS03 ZN C 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 C 1.95 BS04 CA C 1 D158 G190 G192 D194 D53 G85 G87 D89 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 C 1.95 BS05 CA C 2 D124 E199 E201 D19 E94 E96 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 C 1.95 BS06 CA C 3 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 D 1.95 BS01 67M D 1 G178 G179 I180 A182 L214 H218 Q219 H222 H228 P238 Y240 G73 G74 I75 A77 L109 H113 Q114 H117 H123 P133 Y135 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 D 1.95 BS02 ZN D 1 H218 H222 H228 H113 H117 H123 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 D 1.95 BS03 ZN D 2 H168 D170 H183 H196 H63 D65 H78 H91 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 D 1.95 BS04 CA D 1 D158 G190 G192 D194 D53 G85 G87 D89 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 D 1.95 BS05 CA D 2 D124 E199 E201 D19 E94 E96 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i43 D 1.95 BS06 CA D 3 D175 G176 G178 I180 D198 E201 D70 G71 G73 I75 D93 E96 H218 Q219 H222 H228 H113 Q114 H117 H123 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG