5i3m A 2.17 BS01 67F A 1 I180 A182 H183 L214 T215 H218 Q219 H222 H228 F237 P238 T239 Y240 I74 A76 H77 L108 T109 H112 Q113 H116 H122 F131 P132 T133 Y134 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 -logKd/Ki=7.40, IC50=40nM P39900 27356908 301 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m A 2.17 BS02 ZN A 1 H218 H222 H228 H112 H116 H122 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m A 2.17 BS03 ZN A 2 H168 D170 H183 H196 H62 D64 H77 H90 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m A 2.17 BS04 CA A 1 D158 G190 G192 D194 D52 G84 G86 D88 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m A 2.17 BS05 CA A 2 D124 E199 E201 D18 E93 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m A 2.17 BS06 CA A 3 D175 G176 G178 I180 D198 E201 D69 G70 G72 I74 D92 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m B 2.17 BS01 67F B 1 I180 A182 L214 T215 H218 Q219 H222 H228 P238 Y240 I74 A76 L108 T109 H112 Q113 H116 H122 P132 Y134 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m B 2.17 BS02 ZN B 1 H218 H222 H228 H112 H116 H122 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m B 2.17 BS03 ZN B 2 H168 D170 H183 H196 H62 D64 H77 H90 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m B 2.17 BS04 CA B 1 D158 G190 G192 D194 D52 G84 G86 D88 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m B 2.17 BS05 CA B 2 D124 E199 E201 D18 E93 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m B 2.17 BS06 CA B 3 D175 G176 G178 I180 D198 E201 D69 G70 G72 I74 D92 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m C 2.17 BS01 67F C 1 G179 I180 A182 H183 L214 H218 Q219 H228 P238 Y240 G73 I74 A76 H77 L108 H112 Q113 H122 P132 Y134 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m C 2.17 BS02 ZN C 1 H218 H222 H228 H112 H116 H122 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m C 2.17 BS03 ZN C 2 H168 D170 H183 H196 H62 D64 H77 H90 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m C 2.17 BS04 CA C 1 D158 G190 G192 D194 D52 G84 G86 D88 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m C 2.17 BS05 CA C 2 D124 E199 E201 D18 E93 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m C 2.17 BS06 CA C 3 D175 G176 G178 I180 D198 E201 D69 G70 G72 I74 D92 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m D 2.17 BS01 67F D 1 I180 A182 H183 L214 H218 Q219 H222 H228 V235 F237 P238 T239 Y240 I74 A76 H77 L108 H112 Q113 H116 H122 V129 F131 P132 T133 Y134 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 301 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m D 2.17 BS02 ZN D 1 H218 H222 H228 H112 H116 H122 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 302 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m D 2.17 BS03 ZN D 2 H168 D170 H183 H196 H62 D64 H77 H90 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 303 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m D 2.17 BS04 CA D 1 D158 G190 G192 D194 D52 G84 G86 D88 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 304 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m D 2.17 BS05 CA D 2 D124 E199 E201 D18 E93 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 305 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG 5i3m D 2.17 BS06 CA D 3 D175 G176 G178 I180 D198 E201 D69 G70 G72 I74 D92 E95 H218 Q219 H222 H228 H112 Q113 H116 H122 3.4.24.65 0004222,0006508,0008237,0008270,0031012 P39900 27356908 306 PVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTGMADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTTHSGGTNLFLTAVHQIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDIRGIQSLYG