5hzn A 2.2 BS01 66A A 1 G1003 Q1004 G1005 F1007 A1028 K1030 E1047 V1060 M1076 M1079 M1139 G1149 D1150 G24 Q25 G26 F28 A49 K51 E68 V81 M97 M100 M152 G162 D163 D1132 R1136 N1137 D1150 E1159 D145 R149 N150 D163 E172 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM -logKd/Ki=7.21, IC50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn B 2.2 BS01 66A B 1 G1003 A1028 K1030 F1044 E1047 V1060 M1076 M1079 D1083 M1139 D1150 G24 A49 K51 F65 E68 V81 M97 M100 D104 M152 D163 D1132 R1136 N1137 D1150 E1159 D145 R149 N150 D163 E172 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn C 2.2 BS01 66A C 1 G1003 F1007 V1010 A1028 K1030 E1047 V1060 M1076 M1079 D1083 M1139 D1150 G24 F28 V31 A49 K51 E68 V81 M97 M100 D104 M152 D163 D1132 R1136 N1137 D1150 E1159 D145 R149 N150 D163 E172 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn D 2.2 BS01 66A D 1 L1002 G1003 Q1004 V1010 A1028 K1030 F1044 E1047 A1048 V1060 M1076 M1079 D1083 M1139 G1149 D1150 L23 G24 Q25 V31 A49 K51 F65 E68 A69 V81 M97 M100 D104 M160 G170 D171 D1132 R1136 N1137 D1150 E1159 D153 R157 N158 D171 E180 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAMANNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn E 2.2 BS01 66A E 1 G1003 Q1004 G1005 F1007 A1028 K1030 E1047 V1060 M1076 M1079 M1139 D1150 G24 Q25 G26 F28 A49 K51 E68 V81 M97 M100 M152 D163 D1132 R1136 N1137 D1150 E1159 D145 R149 N150 D163 E172 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn F 2.2 BS01 66A F 1 L1002 G1003 A1028 K1030 F1044 E1047 V1060 M1076 M1079 D1083 M1139 L23 G24 A49 K51 F65 E68 V81 M97 M100 D104 M152 D1132 R1136 N1137 D1150 E1159 D145 R149 N150 D163 E172 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn G 2.2 BS01 66A G 1 L1002 G1003 V1010 A1028 K1030 E1047 V1060 M1076 M1079 D1083 M1139 L23 G24 V31 A49 K51 E68 V81 M97 M100 D104 M152 D1132 R1136 N1137 D1150 E1159 D145 R149 N150 D163 E172 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEENK 5hzn H 2.2 BS01 66A H 1 L1002 G1003 Q1004 V1010 A1028 K1030 F1044 E1047 A1048 V1060 M1076 M1079 D1083 M1139 G1149 D1150 L23 G24 Q25 V31 A49 K51 F65 E68 A69 V81 M97 M100 D104 M160 G170 D171 D1132 R1136 N1137 D1150 E1159 D153 R157 N158 D171 E180 2.7.10.1 0004672,0004713,0004714,0005524,0006468,0007169,0016020 ic50=0.061uM IC50=61nM P08069 26951750 1301 AADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPAMANNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIKEEMEPGFREVSFYYSEEN