5hln A 3.1 BS01 65C A 1 I62 G63 N64 F67 V70 A83 Y134 V135 P136 T138 Q185 L188 C199 I29 G30 N31 F34 V37 A50 Y97 V98 P99 T101 Q148 L151 C162 D181 K183 N186 D200 S219 D144 K146 N149 D163 S182 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 -logKd/Ki=11.52, IC50=0.003nM IC50=30nM, EC50=1500nM P49841 27128528 501 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 5hln A 3.1 BS02 MG A 1 D264 E268 D227 E231 D181 K183 N186 D200 S219 D144 K146 N149 D163 S182 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 P49841 27128528 502 GSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARI 5hln B 3.1 BS01 65C B 1 I62 F67 V70 A83 Y134 V135 T138 Q185 L188 I26 F31 V34 A47 Y98 V99 T102 Q149 L152 D181 K183 N186 D200 S219 D145 K147 N150 D164 S183 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 IC50=30nM, EC50=1500nM P49841 27128528 501 VTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR 5hln B 3.1 BS02 MG B 1 D264 E268 D228 E232 D181 K183 N186 D200 S219 D145 K147 N150 D164 S183 2.7.11.1,2.7.11.26 0001837,0001954,0002020,0002039,0003170,0004672,0004674,0005515,0005524,0005634,0005654,0005737,0005739,0005813,0005829,0005886,0005977,0006338,0006468,0006983,0007005,0007212,0007399,0007623,0008013,0008286,0009968,0010508,0010628,0010629,0010719,0010975,0016055,0016301,0016310,0018105,0018107,0019082,0019901,0021766,0030010,0030011,0030154,0030336,0030424,0030425,0030516,0030877,0031175,0031333,0031334,0031398,0031625,0032007,0032092,0032436,0032515,0032886,0034236,0034452,0035556,0036016,0042752,0043066,0043161,0043547,0044024,0045597,0045668,0045719,0045724,0045732,0046777,0046825,0046827,0048156,0048511,0048814,0050321,0050770,0051059,0051093,0051128,0060070,0060079,0061629,0070507,0070885,0071109,0071300,0090090,0097191,0097192,0098793,0098794,0098978,0099171,0106027,0106310,0150101,1900034,1900181,1900271,1901030,1901984,1902042,1903566,1904339,1904646,1904781,1904886,1990909,2000077,2000466,2000740 P49841 27128528 502 VTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHAR