5hie A 3.0 BS01 P06 A 1 G464 G466 V471 A481 K483 L505 L514 F516 T529 W531 C532 F583 D594 F595 G16 G18 V23 A33 K35 L52 L61 F63 T76 W78 C79 F130 D141 F142 D576 K578 N580 N581 D594 S616 D123 K125 N127 N128 D141 S152 2.7.11.1 0004672,0005524,0006468 IC50=1.000000nM, EC50=529nM P15056 26996308 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hie B 3.0 BS01 P06 B 1 G464 S465 V471 A481 K483 F498 L505 L514 T529 W531 C532 F583 D594 F595 G16 S17 V23 A33 K35 F45 L52 L61 T76 W78 C79 F130 D141 F142 D576 K578 N580 N581 D594 S616 D123 K125 N127 N128 D141 S153 2.7.11.1 0004672,0005524,0006468 IC50=1.000000nM, EC50=529nM P15056 26996308 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLATVKSRSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hie C 3.0 BS01 P06 C 1 G464 V471 A481 K483 V504 L514 F516 T529 W531 C532 F583 D594 F595 G16 V23 A33 K35 V51 L61 F63 T76 W78 C79 F130 D141 F142 D576 K578 N580 N581 D594 S616 D123 K125 N127 N128 D141 S147 2.7.11.1 0004672,0005524,0006468 IC50=1.000000nM, EC50=529nM P15056 26996308 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP 5hie D 3.0 BS01 P06 D 1 S465 V471 A481 K483 L514 I527 T529 W531 C532 F583 D594 F595 S17 V23 A33 K35 L61 I74 T76 W78 C79 F130 D141 F142 D576 K578 N580 N581 D594 S616 D123 K125 N127 N128 D141 S147 2.7.11.1 0004672,0005524,0006468 IC50=1.000000nM, EC50=529nM P15056 26996308 801 DWEIPDGQITVGQRIGSGSFGTVYKGKWHGDVAVKMLTPQQLQAFKNEVGVLRKTRHVNILLFMGYSTKPQLAIVTQWCEGSSLYHHLHIIETKFEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIGDFGLSGSILWMAPEVIRMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVGRGYLSPDLSKVRSNCPKAMKRLMAECLKKKRDERPLFPQILASIELLARSLP