5hgq A 3.283 BS01 LYS A 1 A210 E271 N430 Y432 G479 W480 A193 E254 N407 Y409 G439 W440 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 601 EYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKREKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVEAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPA 5hgq A 3.283 BS02 KRS A 1 E257 H263 N264 F267 E427 I428 V429 G483 R486 E240 H246 N247 F250 E404 I405 V406 G443 R446 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 -logKd/Ki=7.34, Kd=45.2nM 27806050 602 EYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKREKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVEAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPA 5hgq B 3.283 BS01 LYS B 1 R255 E271 Y432 R249 E265 Y419 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 601 PQEYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHTHFGNQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVEPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDEQAIDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPAMR 5hgq B 3.283 BS02 KRS B 1 R255 E257 H263 N264 F267 S269 G483 R486 R249 E251 H257 N258 F261 S263 G458 R461 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 602 PQEYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHTHFGNQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVEPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDEQAIDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPAMR 5hgq C 3.283 BS01 LYS C 1 G209 A210 E233 Y273 N430 Y432 G202 A203 E226 Y266 N413 Y415 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 601 EYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHTHFGLNQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTDTDEANKFFDKLAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDEQENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPA 5hgq C 3.283 BS02 KRS C 1 E257 H263 N264 F267 I428 R486 E250 H256 N257 F260 I411 R454 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 602 EYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKRESGGKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHTHFGLNQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTDTDEANKFFDKLAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDEQENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPA 5hgq D 3.283 BS01 LYS D 1 Y273 N430 Y432 G479 Y260 N412 Y414 G444 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 602 QEYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKRESKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHTQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVENAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPA 5hgq D 3.283 BS02 KRS D 1 R255 H263 N264 F267 S269 E427 I428 G483 R486 R242 H250 N251 F254 S256 E409 I410 G448 R451 0000166,0003676,0004812,0004824,0005524,0005737,0006418,0006430 27806050 603 QEYFKLRTALINERRSKGINPYPHKFHVSISLADFIAKYNSLEKDVILNDIVQSVAGRVFSKRESKLIFYDLHGEGTRLQVLANARFHSGDEAFDNLHDRIKRGDIIGVNGYPARSKSGELSIIPYEIIQLTPCLHMLPHTQETRYRMRYLDLIMNPDVKNRFVTRSRMISFLRRYLDNLGFLEVETPMMNLIAGGATAKPFITHHNDLDMDLYLRVAPELYLKMLVVGGIDRVYEIGRVFRNEGIDQTHNPEFTSCEFYMAYADYEDLMKITEDMLARMVYYMHGTYKIQYHPNGIVENPVYEVDFTPPFRKVNIYDGLQEKLGIQFPPADTLDTDEANKFFDKLAVENAPRTTARLLDKLIGEFLEPTFISPTFLTGHPQIMSPLAKWHRSIPGLTERFELFVVTKEIVNAYTELNDPLTQRLRFDENYCTALEYGLPPTAGWGMGIDRLAMILTDSNNIKEVLFFPA