5h8b A 2.55 BS01 5Y2 A 1 V53 V66 K68 I95 V116 N118 M163 I174 D175 V52 V65 K67 I94 V115 N117 M162 I173 D174 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=11.31, Kd=4.91pM IC50=<3.0nM, Kd=4.9nM P68400 26985319 417 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA 5h8b B 2.55 BS01 5Y2 B 1 V53 V66 K68 V116 M163 I174 D175 V52 V65 K67 V115 M162 I173 D174 D156 K158 N161 D175 P184 S194 D155 K157 N160 D174 P183 S193 2.7.11.1 0004672,0004674,0005524,0006468 IC50=<3.0nM, Kd=4.9nM P68400 26985319 420 SGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQA