5h15 A 2.27 BS01 peptide C 0 W103 H104 S105 E107 D109 V112 Y154 S159 H160 P161 P177 I178 R201 L246 L315 G316 D317 L318 M336 L353 F372 W373 Q374 L391 E392 E394 R420 W26 H27 S28 E30 D32 V35 Y77 S82 H83 P84 P100 I101 R124 L169 L231 G232 D233 L234 M252 L269 F288 W289 Q290 L307 E308 E310 R336 ? O75530 28072869 40 ~ 68 CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 5h15 A 2.27 BS02 LQD A 1 F97 Y148 E238 L240 D310 Y365 R367 R414 F20 Y71 E161 L163 D226 Y281 R283 R330 ? ic50=1.57uM -logKd/Ki=5.80, IC50=1.57uM Ki=600nM, Kd=38000nM O75530 28072869 501 CKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 5h15 B 2.27 BS01 peptide D 0 W103 H104 S105 K106 E107 D109 Y154 S159 H160 P161 R201 L246 L247 L315 G316 D317 L318 K332 M336 F372 W373 Q374 L391 E392 E394 R420 W27 H28 S29 K30 E31 D33 Y78 S83 H84 P85 R125 L170 L171 L239 G240 D241 L242 K256 M260 F296 W297 Q298 L315 E316 E318 R344 ? O75530 28072869 40 ~ 68 KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL 5h15 B 2.27 BS02 LQD B 1 F97 Y148 E238 L240 D310 Y365 R367 R414 F21 Y72 E162 L164 D234 Y289 R291 R338 ? ic50=1.57uM Ki=600nM, Kd=38000nM O75530 28072869 501 KCKYSFKCVNSLKEDHNQPLFGVQFNWHSKEGDPLVFATVGSNRVTLYECHSQGEIRLLQSYVDADADENFYTCAWTYDSNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIFGGVEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKESYDYNPNKTNRPFISQKIHFPDFSTRDIHRNYVDCVRWLGDLILSKSCENAIVCWKPGKMEDDIDKIKPSESNVTILGRFDYSQCDIWYMRFSMDFWQKMLALGNQVGKLYVWDLEVEDPHKAKCTTLTHHKCGAAIRQTSFSRDSSILIAVCDDASIWRWDRL