5gvp A 2.26 BS01 PLG A 1 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp A 2.26 BS02 GCF A 1 L124 G128 H129 T183 K355 C364 P367 L124 G128 H129 T183 K355 C364 P367 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 ic50=165nM -logKd/Ki=6.78, Kd=165nM A5K8L9 28537728 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp A 2.26 BS03 GCF A 2 E56 Y63 Y64 E56 Y63 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 ic50=165nM -logKd/Ki=6.78, Kd=165nM A5K8L9 28537728 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp A 2.26 BS04 PLG B 1 Y54 Y64 Y54 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp B 2.26 BS01 PLG A 1 Y54 Y64 Y54 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp B 2.26 BS02 GCF A 1 E56 Y63 Y64 E56 Y63 Y64 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=6.78, Kd=165nM A5K8L9 28537728 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp B 2.26 BS03 GCF A 2 L124 G128 T183 K355 C364 P367 L124 G128 T183 K355 C364 P367 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 -logKd/Ki=6.78, Kd=165nM A5K8L9 28537728 503 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp B 2.26 BS04 PLG B 1 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp C 2.26 BS01 PLG C 1 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 S34 S100 G101 S102 H129 Y182 T183 D208 H211 H236 K237 R371 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 A5K8L9 28537728 501 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP 5gvp C 2.26 BS02 GCF C 1 L124 G128 T183 K355 C364 L124 G128 T183 K355 C364 Y54 E56 D208 T234 K237 R243 Y54 E56 D208 T234 K237 R243 2.1.2.1 0004372,0005737,0006565,0006730,0008270,0016740,0019264,0030170,0035999,0046653,0046655,0050897,0070905 ic50=165nM A5K8L9 28537728 502 MFNNEPLEQIDKELHDILADEEKRQRETINLIASENLTNGAVRECLGNRVSNKYSEGYPKKRYYGGNDFIDKIEELCQKRALEAFNVSDEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDMFESKLYKCNSQGYVDLDAVREMALSFKPKVIICGYTSYPRDIDYQQFRQICDEVNAYLFADISHISSFVACNILNNPFLHADVVTTTTHKILRGPRSALIFFNKKRNPGIEQKINSAVFPSFQGGPHNNKIAAVACQLKEVHSPAFKEYTQQVLLNSKALAKALISKQIDLVTNGTDNHLIVVDLRKFSITGSKLQETCNAINVSLNKNTIPSDVDCVSPSGVRIGTPAMTTRGAKEKDMEFIADVLARAIKITVDLQEQYGKKLVDFKKGLPGNAQLQQLKQEVVTWAGALPFP