5gty A 3.14 BS01 816 A 1 G719 V726 A743 I744 K745 R776 L777 M790 M793 G796 C797 R841 L844 D855 G20 V27 A44 I45 K46 R73 L74 M87 M90 G93 C94 R138 L141 D152 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 -logKd/Ki=7.72, IC50=19.01nM P00533 28407693 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5gty B 3.14 BS01 816 B 1 G719 V726 A743 K745 R776 L777 L788 M790 M793 C797 R841 L844 T854 D855 G20 V27 A44 K46 R73 L74 L85 M87 M90 C94 R138 L141 T151 D152 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5gty C 3.14 BS01 816 C 1 G719 V726 A743 K745 L777 M790 M793 G796 C797 T854 D855 G20 V27 A44 K46 L74 M87 M90 G93 C94 T151 D152 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDA 5gty D 3.14 BS01 816 D 1 L718 G719 V726 A743 K745 R776 L777 L788 M790 L792 M793 G796 C797 L844 T854 D855 L18 G19 V26 A43 K45 R71 L72 L83 M85 L87 M88 G91 C92 L139 T149 D150 D837 A839 R841 N842 D855 D132 A134 R136 N137 D150 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5gty E 3.14 BS01 816 E 1 G719 S720 V726 A743 K745 C775 L788 M790 M793 G796 C797 T854 D855 G19 S20 V26 A43 K45 C70 L83 M85 M88 G91 C92 T149 D150 D837 A839 R841 N842 D855 D132 A134 R136 N137 D150 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 QALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5gty F 3.14 BS01 816 F 1 G719 V726 A743 K745 C775 R776 L777 M790 M793 C797 D855 L858 G20 V27 A44 K46 C72 R73 L74 M87 M90 C94 D152 L155 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDA 5gty G 3.14 BS01 816 G 1 L718 G719 A743 K745 M766 R776 L777 L788 M790 Q791 L792 M793 C797 R841 T854 D855 L20 G21 A45 K47 M63 R73 L74 L85 M87 Q88 L89 M90 C94 R138 T151 D152 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 PNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDAD 5gty H 3.14 BS01 816 H 1 L718 A743 K745 M766 R776 L777 L788 M790 Q791 L792 M793 C797 R841 T854 D855 F856 L19 A44 K46 M63 R73 L74 L85 M87 Q88 L89 M90 C94 R138 T151 D152 F153 D837 A839 R841 N842 D855 D134 A136 R138 N139 D152 2.7.10.1 0004672,0004713,0005524,0006468 P00533 28407693 1101 NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREAANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVADEY