5g22 A 2.32 BS01 NHW A 1 Y28 F30 W31 Y95 V96 L163 C164 V165 R170 S171 R173 A175 I179 T183 I186 W192 A194 Y196 T197 A198 L202 Y393 Y3 F5 W6 Y70 V71 L138 C139 V140 R145 S146 R148 A150 I154 T158 I161 W167 A169 Y171 T172 A173 L177 Y368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 28626547 1000 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 A 2.32 BS02 YN4 A 1 E97 D98 F103 F105 Y211 H213 F226 S319 L330 Y334 L388 L410 E72 D73 F78 F80 Y186 H188 F201 S294 L305 Y309 L363 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=0.1uM -logKd/Ki=7.00, Ki=0.1uM A5K1A2 28626547 1001 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 A 2.32 BS03 MG A 1 K172 L174 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 28626547 1412 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 B 2.32 BS01 NHW B 1 Y28 F30 W31 Y95 V96 N161 L163 C164 V165 R170 S171 R173 A175 I179 T183 I186 W192 Q193 A194 Y196 T197 A198 L202 Y393 Y3 F5 W6 Y70 V71 N136 L138 C139 V140 R145 S146 R148 A150 I154 T158 I161 W167 Q168 A169 Y171 T172 A173 L177 Y368 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 28626547 1000 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 B 2.32 BS02 YN4 B 1 E97 D98 F103 F105 Y211 H213 F226 S319 Y334 L388 L410 E72 D73 F78 F80 Y186 H188 F201 S294 Y309 L363 L385 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=0.1uM A5K1A2 28626547 1001 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 B 2.32 BS03 MG B 1 K172 L174 K147 L149 N161 F162 L163 T197 L410 N136 F137 L138 T172 L385 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 28626547 1411 IDYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFSSLNSRLTMSRAIKLYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 C 2.32 BS01 NHW C 1 Y28 K29 F30 W31 Y95 V96 L163 C164 V165 R170 S171 R173 A175 P176 I179 T183 I186 W192 Q193 A194 Y196 T197 A198 L202 Y393 Y2 K3 F4 W5 Y69 V70 L137 C138 V139 R144 S145 R147 A149 P150 I153 T157 I160 W166 Q167 A168 Y170 T171 A172 L176 Y352 N161 F162 L163 T197 L410 N135 F136 L137 T171 L369 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 28626547 1000 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 C 2.32 BS02 YN4 C 1 E97 D98 F103 F105 G199 Y211 H213 F226 S319 Y334 N365 L388 L410 E71 D72 F77 F79 G173 Y185 H187 F200 S278 Y293 N324 L347 L369 N161 F162 L163 T197 L410 N135 F136 L137 T171 L369 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 Ki=0.1uM A5K1A2 28626547 1001 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL 5g22 C 2.32 BS03 MG C 1 K172 L174 K146 L148 N161 F162 L163 T197 L410 N135 F136 L137 T171 L369 2.3.1.97 0004379,0005737,0006499,0016746,0018008,0046872 A5K1A2 28626547 1411 DYKFWYTQPVPKINDEFNESVNEPFISDNKVEDVRKDEYKLPPGYSWYVCDVKDEKDRSEIYTLLTDNYVEDDDNIFRFNYSAEFLLWALTSPNYLKTWHIGVKYDASNKLIGFISAIPTDICIHKRTIKMAEVNFLCVHKTLRSKRLAPVLIKEITRRINLENIWQAIYTAGVYLPKPVSDARYYHRSINVKKLIEIGFYRVEDTLNIKNMRLMKKKDVEGVHKLLGSYLEQFNLYAVFTKEEIAHWFLPIENVIYTYVNEENGKIKDMISFYSLPSQILGNDKYSTLNAAYSFYNVTTTATFKQLMQDAILLAKRNNFDVFNALEVMQNKSVFEDLKFGEGDGSLKYYLYNWKCASFAPAHVGIVLL