5fqd B 2.45 BS01 ZN B 1 C323 C326 C391 C268 C271 C336 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Q96SW2 26909574 1437 INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPD 5fqd B 2.45 BS02 LVY B 1 N351 P352 E377 H378 W380 W386 W400 F402 N296 P297 E322 H323 W325 W331 W345 F347 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Kd=242nM Ki=1490nM, IC50=2000nM Q96SW2 26909574 1438 INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPD 5fqd C 2.45 BS01 LVY B 1 N39 G40 N30 G31 D136 K138 D127 K129 2.7.11.1 0000775,0000776,0004672,0004674,0005515,0005524,0005634,0005694,0005737,0005813,0005819,0005829,0005847,0005856,0005929,0006338,0006468,0007030,0007165,0007166,0016020,0016055,0016310,0016607,0018105,0019082,0030877,0031670,0032436,0035025,0036064,0042995,0043161,0044024,0045095,0045104,0051301,0090090,0106310,1900226,1904263 P48729 26909574 1438 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQ 5fqd E 2.45 BS01 ZN E 1 C323 C326 C391 C394 C254 C257 C322 C325 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Q96SW2 26909574 1437 INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEIVKVKAIGRQRFKVLEQQAKVQILPECVLPSTMSAVQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPD 5fqd E 2.45 BS02 LVY E 1 N351 P352 H378 S379 W380 W386 W400 F402 N282 P283 H309 S310 W311 W317 W331 F333 ? 0005515,0005634,0005737,0005829,0016020,0016567,0030177,0031333,0031334,0031464,0034766,0035641,0043161,0044325,0046872,0048471,1902607 Kd=242nM Ki=1490nM, IC50=2000nM Q96SW2 26909574 1438 INFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEIVKVKAIGRQRFKVLEQQAKVQILPECVLPSTMSAVQLESLNKCQIFPCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPD 5fqd F 2.45 BS01 LVY E 1 N39 G40 N30 G31 D136 K138 D127 K129 2.7.11.1 0000775,0000776,0004672,0004674,0005515,0005524,0005634,0005694,0005737,0005813,0005819,0005829,0005847,0005856,0005929,0006338,0006468,0007030,0007165,0007166,0016020,0016055,0016310,0016607,0018105,0019082,0030877,0031670,0032436,0035025,0036064,0042995,0043161,0044024,0045095,0045104,0051301,0090090,0106310,1900226,1904263 P48729 26909574 1438 EFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQ