5ewa A 2.3 BS01 ZN A 1 H77 H79 H139 H75 H77 H137 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 301 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa A 2.3 BS02 ZN A 2 D81 C158 H197 D79 C156 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 302 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa A 2.3 BS03 9BZ A 1 W28 D81 H139 K161 H197 W26 D79 H137 K159 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki=15uM -logKd/Ki=4.82, Ki=15uM P52699 27303030 303 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa B 2.3 BS01 ZN B 1 H77 H79 H139 H75 H77 H137 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 301 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa B 2.3 BS02 ZN B 2 D81 C158 H197 D79 C156 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 302 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa B 2.3 BS03 9BZ B 1 W28 D81 K161 N167 H197 W26 D79 K159 N165 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki=15uM P52699 27303030 303 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa C 2.3 BS01 ZN C 1 H77 H79 H139 H75 H77 H137 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 301 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPS 5ewa C 2.3 BS02 ZN C 2 D81 C158 H197 D79 C156 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 302 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPS 5ewa C 2.3 BS03 9BZ C 1 W28 D81 H139 K161 H197 W26 D79 H137 K159 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 Ki=15uM P52699 27303030 304 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKKPS 5ewa D 2.3 BS01 ZN D 1 H77 H79 H139 H75 H77 H137 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 301 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK 5ewa D 2.3 BS02 ZN D 2 D81 C158 H197 D79 C156 H195 H77 H79 D81 H139 C158 K161 N167 H197 H75 H77 D79 H137 C156 K159 N165 H195 3.5.2.6 0008270,0008800,0016787,0017001,0042597,0046677,0046872 P52699 27303030 302 SLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNAEAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELTNELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKPYGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESK