5eom A 2.55 BS01 CTP A 1 R23 K24 I27 I31 R62 Y63 L66 V68 K248 S252 K255 R23 K24 I27 I31 R61 Y62 L65 V67 K238 S242 K245 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 -logKd/Ki=6.39, Kd=0.41uM Q13394 27271801 403 DIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom B 2.55 BS01 CTP B 1 R23 K24 I31 R62 Y63 L66 V68 S252 K255 R26 K27 I34 R65 Y66 L69 V71 S242 K245 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom C 2.55 BS01 TMO C 1 T72 R165 T75 R168 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom C 2.55 BS02 CTP C 1 R23 K24 I31 R62 Y63 L66 S252 K255 R26 K27 I34 R65 Y66 L69 S246 K249 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 404 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom D 2.55 BS01 CTP D 1 R23 K24 I31 R62 Y63 L66 V68 K248 S252 K255 R25 K26 I33 R57 Y58 L61 V63 K231 S235 K238 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 AMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom E 2.55 BS01 CTP E 1 R23 K24 I27 I31 R62 Y63 L66 V68 K248 S252 K255 R23 K24 I27 I31 R61 Y62 L65 V67 K237 S241 K244 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 DIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKESESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom F 2.55 BS01 TMO F 1 S144 Y145 S137 Y138 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQVFNFVDGSLPGCAVLKLSSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPIPWPGPNRVAEVKAEGFNLLSKESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom F 2.55 BS02 CTP F 1 R23 K24 I31 R62 Y63 L66 V68 K248 S252 K255 R26 K27 I34 R65 Y66 L69 V71 K228 S232 K235 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 403 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQVFNFVDGSLPGCAVLKLSSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPIPWPGPNRVAEVKAEGFNLLSKESDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom G 2.55 BS01 CTP G 1 R23 K24 I31 R62 L66 V68 S252 K255 R26 K27 I34 R65 L69 V71 S245 K248 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom H 2.55 BS01 CTP H 1 R23 K24 I31 R62 Y63 L66 V68 K248 S252 K255 R26 K27 I34 R65 Y66 L69 V71 K234 S238 K241 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 403 GAMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNEMDNRYEGLEVISPTEFEVVLYLQMGVFNFVDDGSLPGCAVLKLMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSSDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom I 2.55 BS01 CTP I 1 R23 K24 I31 R62 Y63 K248 R23 K24 I31 R59 Y60 K235 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 402 DIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPRFISSLNERYEGLEVISPTEFEVVLYLNQMGVFNFVDDGSLPGCAVLKLSDGRKRSMSLWVEFITASGYLSARKIRSRFQTLVAQAVDKCSYRDVVKMVADTSEVKLRIRDRYVVQITPAFKCTGIWPRSAAHWPLPHIPWPGPNRVAEVKAEGFNLLSKECHSDAWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL 5eom J 2.55 BS01 CTP J 1 R23 K24 A28 I31 L66 V68 K248 S252 K255 R25 K26 A30 I33 L56 V58 K175 S179 K182 2.7.7.- 0001654,0005515,0005524,0005525,0005634,0008283,0008284,0009653,0016779,0043010,0046872 Q13394 27271801 401 AMDIAAQAKLVYHLNKYYNEKCQARKAAIAKTIREVCKVVSDVLKEVEVQEPYEGLEVISPTEFEVVLYLLPGCAVFITAYLSARKIRSRFQTLVAQAVDKCSYRDVKLRIRDRYVVQITPAKCTGWPRSAAHWPLPHIGPNRVAEVKAEGFNLLSWVLQFAEAENRLQMGGCRKKCLSILKTLRDRHLELPGQPLNNYHMKTLVSYECEKHPRESDWDESCLGDRLNGILLQLISCLQCRRCPHYFLPNLDLFQGKPHSALENAAKQTWRLAREILTNPKSLEKL