5egs A 2.15 BS01 SAH A 1 Y47 Y48 Y51 M60 R66 G90 A91 L96 E112 A113 P139 V140 E141 E155 M166 S169 Y9 Y10 Y13 M22 R28 G52 A53 L58 E74 A75 P101 V102 E103 E117 M128 S131 D63 E155 E164 H317 D25 E117 E126 H277 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26824386 401 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs A 2.15 BS02 5NR A 1 C50 Y51 V56 M60 E155 M157 Y159 E164 H317 C12 Y13 V18 M22 E117 M119 Y121 E126 H277 D63 E155 E164 H317 D25 E117 E126 H277 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Kd=0.97uM -logKd/Ki=6.01, Kd=0.97uM Kd=970nM, IC50=21000nM Q96LA8 26824386 402 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs A 2.15 BS03 5NR A 2 L162 S168 L267 L343 L344 P345 L124 S130 L229 L303 L304 P305 D63 E155 E164 H317 D25 E117 E126 H277 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Kd=0.97uM -logKd/Ki=6.01, Kd=0.97uM Kd=970nM, IC50=21000nM Q96LA8 26824386 403 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs B 2.15 BS01 SAH B 1 Y47 Y51 M60 R66 G90 A91 L96 E112 A113 P139 E155 M166 Y10 Y14 M23 R29 G53 A54 L59 E75 A76 P102 E118 M129 D63 E155 E164 H317 D26 E118 E127 H280 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26824386 401 RTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs B 2.15 BS02 5NR B 1 C50 Y51 V56 M60 E155 M157 Y159 E164 H317 C13 Y14 V19 M23 E118 M120 Y122 E127 H280 D63 E155 E164 H317 D26 E118 E127 H280 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Kd=0.97uM Kd=970nM, IC50=21000nM Q96LA8 26824386 402 RTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs C 2.15 BS01 SAH C 1 Y47 Y48 Y51 M60 R66 G90 A91 I95 L96 E112 A113 P139 V140 E141 E155 M166 S169 Y9 Y10 Y13 M22 R28 G52 A53 I57 L58 E74 A75 P101 V102 E103 E117 M128 S131 D63 E155 E164 H317 D25 E117 E126 H279 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26824386 401 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs C 2.15 BS02 5NR C 1 Y51 V56 M60 E155 M157 Y159 E164 H317 Y13 V18 M22 E117 M119 Y121 E126 H279 D63 E155 E164 H317 D25 E117 E126 H279 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Kd=0.97uM Kd=970nM, IC50=21000nM Q96LA8 26824386 402 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs C 2.15 BS03 5NR C 2 L162 S168 E268 L343 L344 P345 L124 S130 E230 L305 L306 P307 D63 E155 E164 H317 D25 E117 E126 H279 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Kd=0.97uM Kd=970nM, IC50=21000nM Q96LA8 26824386 403 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs D 2.15 BS01 SAH D 1 Y47 Y48 Y51 M60 R66 G90 A91 G92 I95 E112 A113 M166 S169 Y10 Y11 Y14 M23 R29 G53 A54 G55 I58 E75 A76 M129 S132 D63 E155 E164 H317 D26 E118 E127 H276 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26824386 401 RTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5egs D 2.15 BS02 5NR D 1 Y51 V56 M60 E155 M157 Y159 E164 H317 Y14 V19 M23 E118 M120 Y122 E127 H276 D63 E155 E164 H317 D26 E118 E127 H276 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Kd=0.97uM Kd=970nM, IC50=21000nM Q96LA8 26824386 402 RTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED