5e8r A 2.55 BS01 SAH A 1 Y51 M60 R66 G90 E112 A113 P139 V140 E141 M166 S169 Y10 M19 R25 G49 E71 A72 P98 V99 E100 M125 S128 D63 E155 E164 H317 D22 E114 E123 H274 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26598975 1001 ERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5e8r A 2.55 BS02 5L6 A 1 Y51 V56 E59 M60 E155 M157 Y159 H163 E164 H317 Y10 V15 E18 M19 E114 M116 Y118 H122 E123 H274 D63 E155 E164 H317 D22 E114 E123 H274 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 -logKd/Ki=8.70, Kd=2nM IC50=4.0nM, Ki=0.8nM, Kd=6nM Q96LA8 26598975 1002 ERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 5e8r B 2.55 BS01 SAH B 1 Y51 M60 R66 G90 A91 L96 E112 A113 P139 V140 E141 M166 S169 Y12 M21 R27 G51 A52 L57 E73 A74 P100 V101 E102 M127 S130 D63 E155 E164 H317 D24 E116 E125 H276 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26598975 1001 KRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAME 5e8r B 2.55 BS02 5L6 B 1 Y51 V56 E59 M60 E155 M157 Y159 E164 H317 Y12 V17 E20 M21 E116 M118 Y120 E125 H276 D63 E155 E164 H317 D24 E116 E125 H276 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 IC50=4.0nM, Ki=0.8nM, Kd=6nM Q96LA8 26598975 1002 KRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIVPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELEAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAME