5dhu A 2.33 BS01 5A8 A 1 E123 Y163 S166 H223 E122 Y162 S165 H222 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM -logKd/Ki=6.30, Ki=0.5uM Q8Y8D7 27783975 302 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhu A 2.33 BS02 5A8 C 1 G131 P132 R148 G149 D150 A185 G130 P131 R147 G148 D149 A184 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM -logKd/Ki=6.30, Ki=0.5uM Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhu B 2.33 BS01 5A8 B 1 E123 A162 Y163 S166 H223 E119 A157 Y158 S161 H218 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM Q8Y8D7 27783975 302 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhu B 2.33 BS02 5A8 D 1 G131 P132 R148 G149 D150 A185 G126 P127 R143 G144 D145 A180 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhu C 2.33 BS01 5A8 A 1 G131 P132 R148 G149 D150 A185 G122 P123 R139 G140 D141 A176 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM -logKd/Ki=6.30, Ki=0.5uM Q8Y8D7 27783975 302 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhu C 2.33 BS02 5A8 C 1 E123 A162 Y163 S166 D222 H223 E114 A153 Y154 S157 D213 H214 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM -logKd/Ki=6.30, Ki=0.5uM Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhu D 2.33 BS01 5A8 B 1 P132 R148 G149 D150 A185 P113 R129 G130 D131 A166 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM Q8Y8D7 27783975 302 KYMITSKGDEKSDLLRLNMIAGFDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhu D 2.33 BS02 5A8 D 1 N122 E123 A162 Y163 S166 H223 N103 E104 A143 Y144 S147 H204 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=0.5uM Q8Y8D7 27783975 301 KYMITSKGDEKSDLLRLNMIAGFDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE