5dht A 2.59 BS01 5A9 A 1 N122 E123 A162 Y163 S166 N121 E122 A161 Y162 S165 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 -logKd/Ki=6.00, Ki=1uM Q8Y8D7 27783975 303 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dht A 2.59 BS02 5A9 C 1 P132 G149 D150 A185 P131 G148 D149 A184 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 -logKd/Ki=6.00, Ki=1uM Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dht B 2.59 BS01 5A9 B 1 N122 E123 A162 Y163 S166 H223 N114 E115 A154 Y155 S158 H215 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Q8Y8D7 27783975 302 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAYQKVSYPLLKTTVKYEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dht B 2.59 BS02 5A9 D 1 G131 P132 G123 P124 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Q8Y8D7 27783975 302 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAYQKVSYPLLKTTVKYEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dht C 2.59 BS01 5A9 A 1 G131 P132 G149 D150 G128 P129 G146 D147 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Q8Y8D7 27783975 303 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dht C 2.59 BS02 5A9 C 1 N122 E123 A162 Y163 S166 H223 N119 E120 A159 Y160 S163 H220 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dht D 2.59 BS01 5A9 B 1 P132 R148 G149 D150 P119 R135 G136 D137 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Q8Y8D7 27783975 302 YMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLQKVSYPLLKTTVKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dht D 2.59 BS02 5A9 D 1 N122 E123 A162 Y163 S166 D222 H223 N109 E110 A149 Y150 S153 D209 H210 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Q8Y8D7 27783975 302 YMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLQKVSYPLLKTTVKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE