5dhp A 2.27 BS01 5AQ A 1 N122 E123 Y163 S166 H223 N121 E122 Y162 S165 H222 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM -logKd/Ki=3.85, Ki=140uM Q8Y8D7 27783975 303 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhp A 2.27 BS02 5AQ C 1 G131 P132 D150 G130 P131 D149 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM -logKd/Ki=3.85, Ki=140uM Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGIKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIED 5dhp B 2.27 BS01 5AQ B 1 N122 E123 A162 Y163 S166 D222 H223 N118 E119 A158 Y159 S162 D218 H219 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM Q8Y8D7 27783975 302 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIEDLEH 5dhp C 2.27 BS01 5AQ A 1 G131 P132 G149 D150 A185 G129 P130 G147 D148 A183 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM Q8Y8D7 27783975 303 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhp C 2.27 BS02 5AQ C 1 N122 E123 A162 Y163 S166 D222 N120 E121 A160 Y161 S164 D220 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM Q8Y8D7 27783975 301 MKYMITSKGDEKSDLLRLNMIAGFGEYDMEYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKYGKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhp D 2.27 BS01 5AQ B 1 P132 G149 D150 P119 G136 D137 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM Q8Y8D7 27783975 302 KYMITSKGDEKSDLLRLNMIAGYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE 5dhp D 2.27 BS02 5AQ D 1 N122 E123 A162 Y163 S166 H223 N109 E110 A149 Y150 S153 H210 2.7.1.23 0003951,0005524,0005737,0006741,0016301,0016310,0019674,0046872,0051287 Ki=140uM Q8Y8D7 27783975 302 KYMITSKGDEKSDLLRLNMIAGYDDVEPEIVISIGGDGTFLSAFHQYEERLDEIAFIGIHTGHLGFYADWRPAEADKLVKLLAKGEYQKVSYPLLKTTVKKEATYLALNESTVKSSGGPFVVDVVINDIHFERFRGDGLCMSTPSGTTAYNKSLGGALMHPSIEAMQLTEMASINNRVYRTIGSPLVFPKHHVVSLQPVNDKDFQISVDHLSILHRDVQEIRYEVSAKKIHFARFRSFPFWRRVHDSFIE