5csh A 1.59 BS01 54E A 1 F121 P159 V162 I164 M225 F118 P156 V159 I161 M222 D156 K158 N161 D175 P184 S194 D153 K155 N158 D172 P181 S191 2.7.11.1 0004672,0004674,0005524,0006468 Kd=270uM -logKd/Ki=3.57, Kd=270uM IC50=500000nM P68400 28451126 401 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5csh A 1.59 BS02 54E A 2 Y39 I69 D103 T108 A110 Y36 I66 D100 T105 A107 D156 K158 N161 D175 P184 S194 D153 K155 N158 D172 P181 S191 2.7.11.1 0004672,0004674,0005524,0006468 Kd=270uM -logKd/Ki=3.57, Kd=270uM IC50=500000nM P68400 28451126 402 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5csh A 1.59 BS03 ATP A 1 V66 V116 M163 V63 V113 M160 D156 K158 N161 D175 P184 S194 D153 K155 N158 D172 P181 S191 2.7.11.1 0004672,0004674,0005524,0006468 P68400 28451126 403 PVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTV 5csh B 1.59 BS01 54E B 1 Y136 P159 V162 I164 Y131 P154 V157 I159 D156 K158 N161 D175 P184 S194 D151 K153 N156 D170 P179 S189 2.7.11.1 0004672,0004674,0005524,0006468 Kd=270uM IC50=500000nM P68400 28451126 403 SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 5csh B 1.59 BS02 54E B 2 W24 H183 Q186 W23 H178 Q181 D156 K158 N161 D175 P184 S194 D151 K153 N156 D170 P179 S189 2.7.11.1 0004672,0004674,0005524,0006468 Kd=270uM IC50=500000nM P68400 28451126 404 SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV 5csh B 1.59 BS03 ATP B 1 V53 V66 V116 K158 H160 M163 I174 V52 V65 V115 K153 H155 M158 I169 D156 K158 N161 D175 P184 S194 D151 K153 N156 D170 P179 S189 2.7.11.1 0004672,0004674,0005524,0006468 P68400 28451126 405 SGPVPSRARVYTDVNTHRPSEYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVV