5cr5 A 1.61 BS01 PLP A 1 R99 K202 Y207 E237 T240 N242 L266 G268 V269 V270 T313 R92 K195 Y200 E230 T233 N235 L259 G261 V262 V263 T306 K202 K195 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26288694 401 SSFKAADLQLEMTQKPHKKPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5cr5 A 1.61 BS02 EL1 A 1 F30 F75 Y173 V182 Q224 V238 G239 T240 M241 G312 A314 C318 F23 F68 Y166 V175 Q217 V231 G232 T233 M234 G305 A307 C311 K202 K195 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=2uM IC50=2000nM O15382 26288694 402 SSFKAADLQLEMTQKPHKKPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5cr5 B 1.61 BS01 PLP B 1 R99 K202 Y207 E237 T240 N242 L266 G268 V269 V270 T313 R93 K196 Y201 E231 T234 N236 L260 G262 V263 V264 T307 K202 K196 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26288694 401 SSFKAADLQLEMTQKPHKKPGLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5cr5 B 1.61 BS02 EL1 B 1 F30 F75 Y173 Q224 V238 G239 T240 M241 G310 G312 A314 C318 F24 F69 Y167 Q218 V232 G233 T234 M235 G304 G306 A308 C312 K202 K196 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=2uM IC50=2000nM O15382 26288694 402 SSFKAADLQLEMTQKPHKKPGLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFPGGSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV