5coq A 2.3 BS01 NAD A 1 G14 I16 S20 I21 F41 V65 S94 I95 G96 I122 M147 D148 F149 K165 G192 P193 I194 T196 A198 G13 I15 S19 I20 F40 V64 S93 I94 G95 I121 M146 D147 F148 K164 G191 P192 I193 T195 A197 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 P9WGR1 26147157 300 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAGGEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq A 2.3 BS02 TCU A 1 G96 F97 M103 F149 Y158 M161 A198 M199 G95 F96 M102 F148 Y157 M160 A197 M198 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=427.5nM Ki=913nM, IC50=51nM P9WGR1 26147157 301 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAGGEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq B 2.3 BS01 NAD B 1 G14 I16 S20 I21 F41 L63 D64 V65 S94 I95 G96 I122 M147 D148 F149 K165 A191 P193 I194 T196 A198 G13 I15 S19 I20 F40 L62 D63 V64 S93 I94 G95 I121 M146 D147 F148 K164 A190 P192 I193 T195 A197 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 P9WGR1 26147157 300 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq B 2.3 BS02 TCU B 1 G96 F97 F149 Y158 A198 M199 G95 F96 F148 Y157 A197 M198 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=427.5nM Ki=913nM, IC50=51nM P9WGR1 26147157 301 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq C 2.3 BS01 NAD C 1 G14 I16 S20 I21 F41 D64 S94 I95 G96 I122 M147 D148 F149 K165 P193 I194 T196 A198 G13 I15 S19 I20 F40 D63 S93 I94 G95 I121 M146 D147 F148 K164 P192 I193 T195 A197 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 P9WGR1 26147157 301 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq C 2.3 BS02 TCU C 1 G96 F97 M103 F149 Y158 M161 A198 G95 F96 M102 F148 Y157 M160 A197 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=427.5nM Ki=913nM, IC50=51nM P9WGR1 26147157 302 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq D 2.3 BS01 NAD D 1 G14 I16 S20 I21 F41 V65 S94 I95 G96 I122 M147 D148 F149 K165 P193 I194 T196 A198 G13 I15 S19 I20 F40 V64 S93 I94 G95 I121 M146 D147 F148 K164 P192 I193 T195 A197 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 P9WGR1 26147157 300 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL 5coq D 2.3 BS02 TCU D 1 G96 F97 M103 F149 Y158 M161 A198 M199 I202 I215 G95 F96 M102 F148 Y157 M160 A197 M198 I201 I208 Y158 K165 Y157 K164 1.3.1.9 0004318,0005504,0005886,0006633,0009274,0016491,0030497,0046677,0050343,0070403,0071768 Ki=427.5nM Ki=913nM, IC50=51nM P9WGR1 26147157 301 TGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIAEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL