5bww A 1.82 BS01 PLP A 1 R99 K202 Y207 E237 T240 M241 N242 L266 G268 V269 V270 G312 T313 R94 K190 Y195 E225 T228 M229 N230 L254 G256 V257 V258 G300 T301 K202 K190 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26090771 401 SSFKAADLQLEMTQKPHKKPGPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5bww A 1.82 BS02 4W6 A 1 R143 V182 Q224 V238 T240 M241 A314 C315 R138 V170 Q212 V226 T228 M229 A302 C303 K202 K190 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=0.5uM IC50=<10000nM O15382 26090771 402 SSFKAADLQLEMTQKPHKKPGPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5bww B 1.82 BS01 PLP B 1 R99 R192 K202 Y207 E237 T240 L266 G268 V269 V270 T313 R94 R180 K190 Y195 E225 T228 L254 G256 V257 V258 T301 K202 K190 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26090771 401 SSSFKAADLQLEMTQKPHKKPGLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5bww B 1.82 BS02 4W6 B 1 F75 Y141 Q224 T240 M241 A314 C315 C318 F70 Y136 Q212 T228 M229 A302 C303 C306 K202 K190 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=0.5uM IC50=<10000nM O15382 26090771 402 SSSFKAADLQLEMTQKPHKKPGLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV