5bwu A 2.17 BS01 PLP A 1 R99 K202 Y207 E237 T240 M241 L266 G268 V269 V270 T313 R95 K191 Y196 E226 T229 M230 L255 G257 V258 V259 T302 K202 K191 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26090771 401 SSFKAADLQLEMTQKPHKKPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5bwu A 2.17 BS02 4VR A 1 Y141 R143 V182 Q224 V238 T240 M241 A314 C318 Y137 R139 V171 Q213 V227 T229 M230 A303 C307 K202 K191 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=0.63uM IC50=794nM O15382 26090771 402 SSFKAADLQLEMTQKPHKKPGEPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5bwu B 2.17 BS01 PLP B 1 R99 K202 Y207 E237 T240 N242 L266 G268 V269 V270 T313 R94 K194 Y199 E229 T232 N234 L258 G260 V261 V262 T305 K202 K194 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 O15382 26090771 401 SSFKAADLQLEMTQKPHKKPGPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV 5bwu B 2.17 BS02 4VR B 1 Y141 Q224 V238 T240 M241 A314 C315 C318 Y136 Q216 V230 T232 M233 A306 C307 C310 K202 K194 2.6.1.42 0003824,0004084,0005515,0005654,0005739,0005759,0006549,0006550,0006551,0006573,0006629,0008483,0008652,0009081,0009082,0009083,0009098,0009099,0010817,0050048,0052654,0052655,0052656,1990830 ic50=0.63uM IC50=794nM O15382 26090771 402 SSFKAADLQLEMTQKPHKKPGPLVFGKTFTDHMLMVEWNDKGWGQPRIQPFQNLTLHPASSSLHYSLQLFEGMKAFKGKDQQVRLFRPWLNMDRMLRSAMRLCLPSFDKLELLECIRRLIEVDKDWVPDAAGTSLYVRPVLIGNEPSLGVSQPTRALLFVILCPVGAYFSVTPVSLLADPAFIRAWVGGVGNYKLGGNYGPTVLVQQEALKRGCEQVLWLYGPDHQLTEVGTMNIFVYWTHEDGVLELVTPPLNGVILPGVVRQSLLDMAQTWGEFRVVERTITMKQLLRALEEGRVREVFGSGTACQVCPVHRILYKDRNLHIPTMENGPELILRFQKELKEIQYGIRAHEWMFPV