5btr A 3.2 BS01 peptide D 0 T209 N226 R274 H363 V412 F414 G415 E416 N417 L418 V445 R446 T49 N66 R114 H203 V252 F254 G255 E256 N257 L258 V285 R286 P271 D272 F273 R274 N346 D348 H363 P111 D112 F113 R114 N186 D188 H203 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 1 ~ 4 DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY 5btr A 3.2 BS02 peptide E 0 F148 D150 P180 F5 D7 P20 P271 D272 F273 R274 N346 D348 H363 P111 D112 F113 R114 N186 D188 H203 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 1 ~ 4 DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY 5btr A 3.2 BS03 ZN A 1 C371 C374 C395 C398 C211 C214 C235 C238 P271 D272 F273 R274 N346 D348 H363 P111 D112 F113 R114 N186 D188 H203 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 701 DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY 5btr A 3.2 BS04 STL A 1 T209 P212 D292 Q294 D298 K444 T49 P52 D132 Q134 D138 K284 P271 D272 F273 R274 N346 D348 H363 P111 D112 F113 R114 N186 D188 H203 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 702 DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY 5btr A 3.2 BS05 STL D 1 L206 P211 I223 N226 E230 R446 P447 L46 P51 I63 N66 E70 R286 P287 P271 D272 F273 R274 N346 D348 H363 P111 D112 F113 R114 N186 D188 H203 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 101 DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY 5btr A 3.2 BS06 STL D 2 L215 Q222 F414 G415 L55 Q62 F254 G255 P271 D272 F273 R274 N346 D348 H363 P111 D112 F113 R114 N186 D188 H203 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 102 DNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNPVKLSEITEQYLFLPPNRYIFHGAEVY 5btr B 3.2 BS01 peptide E 0 N226 H363 V412 F414 G415 E416 L418 R446 N68 H205 V254 F256 G257 E258 L260 R288 P271 D272 F273 R274 N346 D348 H363 P113 D114 F115 R116 N188 D190 H205 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 1 ~ 4 SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQYLFLPPNRYIFHGAEVY 5btr B 3.2 BS02 peptide F 0 D150 P180 D9 P22 P271 D272 F273 R274 N346 D348 H363 P113 D114 F115 R116 N188 D190 H205 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 1 ~ 4 SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQYLFLPPNRYIFHGAEVY 5btr B 3.2 BS03 ZN B 1 C374 C395 C398 C216 C237 C240 P271 D272 F273 R274 N346 D348 H363 P113 D114 F115 R116 N188 D190 H205 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 701 SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQYLFLPPNRYIFHGAEVY 5btr B 3.2 BS04 STL B 1 R274 D292 Q294 A295 D298 F414 K444 R116 D134 Q136 A137 D140 F256 K286 P271 D272 F273 R274 N346 D348 H363 P113 D114 F115 R116 N188 D190 H205 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 702 SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQYLFLPPNRYIFHGAEVY 5btr B 3.2 BS05 STL B 2 Q222 G415 Q64 G257 P271 D272 F273 R274 N346 D348 H363 P113 D114 F115 R116 N188 D190 H205 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 703 SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQYLFLPPNRYIFHGAEVY 5btr B 3.2 BS06 STL E 1 L206 P211 I223 N226 E230 R446 P447 L48 P53 I65 N68 E72 R288 P289 P271 D272 F273 R274 N346 D348 H363 P113 D114 F115 R116 N188 D190 H205 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 101 SRDNLLFGDEIITNGSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGAGVSVSSGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSSNITEQYLFLPPNRYIFHGAEVY 5btr C 3.2 BS01 peptide D 0 F148 D150 P180 F5 D7 P18 N346 D348 H363 N166 D168 H183 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 1 ~ 4 DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSFLPPNRYIFH 5btr C 3.2 BS02 peptide F 0 T209 N226 F297 H363 V412 F413 F414 E416 N417 R446 P447 T47 N64 F117 H183 V223 F224 F225 E227 N228 R257 P258 N346 D348 H363 N166 D168 H183 2.3.1.-,2.3.1.286 0070403 Q96EB6 26109052 1 ~ 4 DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSFLPPNRYIFH 5btr C 3.2 BS03 STL C 1 D292 Q294 D298 K444 D112 Q114 D118 K255 N346 D348 H363 N166 D168 H183 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 702 DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSFLPPNRYIFH 5btr C 3.2 BS04 STL C 2 I223 F414 G415 I61 F225 G226 N346 D348 H363 N166 D168 H183 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 703 DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSFLPPNRYIFH 5btr C 3.2 BS05 STL F 1 L206 P211 I223 N226 E230 R446 P447 L450 L44 P49 I61 N64 E68 R257 P258 L261 N346 D348 H363 N166 D168 H183 2.3.1.-,2.3.1.286 0070403 EC50=46200nM Q96EB6 26109052 101 DNLLFGDEIITNDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQESKKIIVLTGYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLSFLPPNRYIFH