5bot A 1.85 BS01 4UM A 1 H222 A238 L239 F241 P242 T245 T247 H119 A135 L136 F138 P139 T142 T144 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=39uM -logKd/Ki=4.41, IC50=39uM IC50=39000nM P45452 22017539 301 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGFMLPDDDVQGIQSLYGPGDED 5bot A 1.85 BS02 ZN A 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 302 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGFMLPDDDVQGIQSLYGPGDED 5bot A 1.85 BS03 ZN A 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 303 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGFMLPDDDVQGIQSLYGPGDED 5bot A 1.85 BS04 CA A 1 D128 D203 E205 D25 D100 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 304 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGFMLPDDDVQGIQSLYGPGDED 5bot A 1.85 BS05 CA A 2 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 305 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGFMLPDDDVQGIQSLYGPGDED 5bot A 1.85 BS06 CA A 3 D162 N194 G196 D198 D59 N91 G93 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 306 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGFMLPDDDVQGIQSLYGPGDED 5bot B 1.85 BS01 4UM B 1 H222 A238 L239 F241 P242 I243 Y244 T245 H119 A135 L136 F138 P139 I140 Y141 T142 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 ic50=39uM IC50=39000nM P45452 22017539 301 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5bot B 1.85 BS02 ZN B 1 H222 H226 H232 H119 H123 H129 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 302 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5bot B 1.85 BS03 ZN B 2 H172 D174 H187 H200 H69 D71 H84 H97 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 303 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5bot B 1.85 BS04 CA B 1 D128 D203 E205 D25 D100 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 304 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5bot B 1.85 BS05 CA B 2 D179 G180 S182 L184 D202 E205 D76 G77 S79 L81 D99 E102 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 305 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG 5bot B 1.85 BS06 CA B 3 D162 N194 Y195 G196 D198 D59 N91 Y92 G93 D95 H222 E223 H226 H232 H119 E120 H123 H129 3.4.24.- 0004222,0006508,0008237,0008270,0031012 P45452 22017539 306 YNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPG