5afn A 2.149 BS01 L0B A 1 W145 C186 Y191 W146 C187 Y192 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn A 2.149 BS02 OJD A 1 M56 V85 L88 A90 P97 Q121 M57 V86 L89 A91 P98 Q122 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=34uM -logKd/Ki=4.47, IC50=34uM P36544,P58154 25918415 1215 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn A 2.149 BS03 L0B E 1 W53 Q55 Q114 L116 W54 Q56 Q115 L117 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn B 2.149 BS01 L0B A 1 W53 Q114 W54 Q115 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKGRS 5afn B 2.149 BS02 L0B B 1 Y91 W145 C186 C187 Y191 Y92 W146 C187 C188 Y192 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1207 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKGRS 5afn B 2.149 BS03 OJD B 1 M56 P86 L88 A90 P97 Q121 F142 M57 P87 L89 A91 P98 Q122 F143 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=34uM -logKd/Ki=4.47, IC50=34uM P36544,P58154 25918415 1217 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKGRS 5afn C 2.149 BS01 L0B B 1 W53 Q114 L116 W54 Q115 L117 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1207 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn C 2.149 BS02 L0B C 1 Y91 W145 Y184 C186 Y191 Y92 W146 Y185 C187 Y192 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn C 2.149 BS03 OJD C 1 M56 V85 A90 P97 Y115 I119 Q121 M57 V86 A91 P98 Y116 I120 Q122 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=34uM P36544,P58154 25918415 1215 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn D 2.149 BS01 L0B C 1 W53 Q55 Q114 L116 W54 Q56 Q115 L117 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn D 2.149 BS02 L0B D 1 Y91 W145 Y184 C186 Y191 Y92 W146 Y185 C187 Y192 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn D 2.149 BS03 OJD D 1 M56 V85 P86 P97 Q121 M57 V86 P87 P98 Q122 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=34uM P36544,P58154 25918415 1215 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn E 2.149 BS01 L0B D 1 W53 Q114 L116 W54 Q115 L117 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn E 2.149 BS02 L0B E 1 Y91 W145 Y184 C186 Y191 Y92 W146 Y185 C187 Y192 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 P36544,P58154 25918415 1205 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG 5afn E 2.149 BS03 OJD E 1 M56 V85 A90 P97 Q121 M57 V86 A91 P98 Q122 ? 0004888,0005216,0005230,0006811,0016020,0022848,0034220,0045211 ic50=34uM P36544,P58154 25918415 1215 GEFQRKLYKELVKNYNPDVIPTQRDRPVTVYFSLSLLQIMDVDEKNQVVDVVFWLQMSWTDHYLQWNVSEYPGVKQVSVPISSLWVPDLAAYNAISKPEVLTPQLALVNSSGHVQYLPSIRQRFSCDVSGVDTESGATCKLKFGSWTHHSRELDLQMQEADISGYIPYSRFELVGVTQKRSERFYECCKEPYPDVTFTVTFRKKG