5a4e A 2.68 BS01 7QQ A 1 F238 L294 D307 F105 L161 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 -logKd/Ki=6.40, IC50=0.4uM Q13627 27736065 1482 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKTEYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 5a4e B 2.68 BS01 7QQ B 1 A186 K188 F238 L241 D307 A54 K56 F100 L103 D169 D287 K289 N292 D307 S324 D149 K151 N154 D169 S186 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 27736065 1482 RKVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFYKPPGTRKLHNILGVETGGPGGRRAGESGHTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK 5a4e C 2.68 BS01 7QQ C 1 F170 A186 K188 F238 L294 V306 F37 A53 K55 F103 L159 V171 D287 K289 N292 D307 S324 D152 K154 N157 D172 S189 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 27736065 1475 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVAPKARKILRMLDYDPKTRIQPYYA 5a4e D 2.68 BS01 7QQ D 1 A186 K188 L241 L294 D307 A53 K55 L108 L161 D174 D287 K289 N292 D307 S324 D154 K156 N159 D174 S191 2.7.11.23,2.7.12.1 0004672,0004712,0005524,0006468,0046777 Q13627 27736065 1482 KVYNDGYDDDNYDYIVKNGEKWMDRYEIDSLIGKGSFGQVVKAYDRVEQEWVAIKIIKNKKAFLNQAQIEVRLLELMNKHDTEMKYYIVHLKRHFMFRNHLCLVFEMLSYNLYDLLRNTNFRGVSLNLTRKFAQQMCTALLFLATPELSIIHCDLKPENILLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGMPYDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLGIPPAHILDQAPKARKFFEKLPDGTWNLKKYKPPGTRKLHNILGVETGGPGGTVADYLKFKDLILRMLDYDPKTRIQPYYALQHSFFK