4zvv A 2.2 BS01 NAD A 1 G28 V30 D51 V52 I53 T94 A95 G96 R98 I115 V135 N137 H192 I251 G28 V30 D51 V52 I53 T94 A95 G96 R98 I115 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 27479743 401 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv A 2.2 BS02 GN0 A 1 N137 D165 R168 H192 G193 D194 V234 A237 Y238 I241 T247 N137 D165 R168 H192 G193 D194 V234 A237 Y238 I241 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=0.003uM IC50=424nM, EC50=7.2nM P00338 27479743 405 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv B 2.2 BS01 NAD B 1 V30 D51 V52 T94 A95 R98 I115 V135 N137 H192 I251 V30 D51 V52 T94 A95 R98 I115 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 27479743 401 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv B 2.2 BS02 GN0 B 1 R98 N137 D165 R168 H192 G193 A237 Y238 I241 T247 R98 N137 D165 R168 H192 G193 A237 Y238 I241 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=0.003uM IC50=424nM, EC50=7.2nM P00338 27479743 404 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv C 2.2 BS01 NAD C 1 V30 D51 V52 I53 T94 A95 G96 R98 I119 V135 N137 H192 I251 V30 D51 V52 I53 T94 A95 G96 R98 I119 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 27479743 401 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv C 2.2 BS02 GN0 C 1 R98 N137 D165 R168 H192 G193 A237 Y238 I241 R98 N137 D165 R168 H192 G193 A237 Y238 I241 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=0.003uM IC50=424nM, EC50=7.2nM P00338 27479743 403 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv D 2.2 BS01 NAD D 1 G28 V30 D51 V52 I53 T94 A95 G96 I115 F118 I119 V135 N137 H192 I251 G28 V30 D51 V52 I53 T94 A95 G96 I115 F118 I119 V135 N137 H192 I251 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 P00338 27479743 401 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF 4zvv D 2.2 BS02 GN0 D 1 N137 D165 R168 H192 G193 A237 Y238 I241 T247 N137 D165 R168 H192 G193 A237 Y238 I241 T247 R105 D165 R168 H192 R105 D165 R168 H192 1.1.1.27 0003824,0004459,0005515,0005634,0005737,0005739,0005829,0006089,0006090,0006096,0016020,0016491,0016616,0019752,0042802,0045296,0070062,1990204 ic50=0.003uM IC50=424nM, EC50=7.2nM P00338 27479743 403 ATLKDQLIYNLLKEEQTPQNKITVVGVGAVGMACAISILMKDLADELALVDVIEDKLKGEMMDLQHGSLFLRTPKIVSGKDYNVTANSKLVIITAGARQQEGESRLNLVQRNVNIFKFIIPNVVKYSPNCKLLIVSNPVDILTYVAWKISGFPKNRVIGSGCNLDSARFRYLMGERLGVHPLSCHGWVLGEHGDSSVPVWSGMNVAGVSLKTLHPDLGTDKDKEQWKEVHKQVVESAYEVIKLKGYTSWAIGLSVADLAESIMKNLRRVHPVSTMIKGLYGIKDDVFLSVPCILGQNGISDLVKVTLTSEEEARLKKSADTLWGIQKELQF