4ztn A 2.23 BS01 4S3 A 1 M192 V200 A211 K213 Y262 Y264 M265 G268 D272 L318 M30 V38 A49 K51 Y96 Y98 M99 G102 D106 L152 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T181 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=19nM -logKd/Ki=7.72, IC50=19nM IC50=19nM Q9NWZ3 26288698 501 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4ztn B 2.23 BS01 4S3 B 1 M192 V200 A211 K213 Y262 Y264 M265 P266 G268 S269 D272 L318 M32 V40 A51 K53 Y92 Y94 M95 P96 G98 S99 D102 L148 D311 K313 A315 N316 D329 T351 D141 K143 A145 N146 D159 T177 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=19nM IC50=19nM Q9NWZ3 26288698 501 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4ztn C 2.23 BS01 4S3 C 1 M192 G193 K213 Y262 Y264 M265 D272 L318 M29 G30 K50 Y94 Y96 M97 D104 L150 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T178 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=19nM IC50=19nM Q9NWZ3 26288698 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 4ztn D 2.23 BS01 4S3 D 1 M192 V200 A211 K213 Y262 Y264 M265 G268 D272 L318 M29 V37 A48 K50 Y95 Y97 M98 G101 D105 L151 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=19nM IC50=19nM Q9NWZ3 26288698 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA