4ztm A 2.66 BS01 4S2 A 1 M192 V200 A211 K213 V246 Y262 Y264 M265 P266 G268 D272 A315 L318 S328 M31 V39 A50 K52 V80 Y96 Y98 M99 P100 G102 D106 A149 L152 S162 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T182 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 -logKd/Ki=7.60, IC50=25nM IC50=25nM Q9NWZ3 26288698 501 DTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4ztm B 2.66 BS01 4S2 B 1 M192 K213 V246 Y262 Y264 M265 P266 G268 D272 A315 L318 S328 M32 K53 V76 Y92 Y94 M95 P96 G98 D102 A145 L148 S158 D311 K313 A315 N316 D329 T351 D141 K143 A145 N146 D159 T175 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=25nM Q9NWZ3 26288698 501 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLLKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4ztm C 2.66 BS01 4S2 C 1 M192 K213 V246 Y262 Y264 M265 P266 G268 L318 M29 K50 V78 Y91 Y93 M94 P95 G97 L147 D311 K313 A315 N316 D329 T351 D140 K142 A144 N145 D158 T176 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=25nM Q9NWZ3 26288698 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 4ztm D 2.66 BS01 4S2 D 1 M192 E194 V200 V246 Y262 Y264 M265 P266 G268 S269 A315 L318 M29 E31 V36 V77 Y93 Y95 M96 P97 G99 S100 A146 L149 D311 K313 A315 N316 D329 T351 D142 K144 A146 N147 D160 T177 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=25nM Q9NWZ3 26288698 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA