4ztl A 2.39 BS01 4S1 A 1 M192 V200 A211 Y262 Y264 M265 A315 L318 D329 M28 V36 A47 Y93 Y95 M96 A146 L149 D160 D311 K313 A315 N316 D329 T351 D142 K144 A146 N147 D160 T175 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=1.2uM -logKd/Ki=5.92, IC50=1.2uM IC50=1193000nM Q9NWZ3 26288698 501 FHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4ztl B 2.39 BS01 4S1 B 1 M192 Y262 Y264 M265 G268 A315 L318 S328 D329 M28 Y81 Y83 M84 G87 A134 L137 S147 D148 D311 K313 A315 N316 D329 T351 D130 K132 A134 N135 D148 T164 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=1.2uM IC50=1193000nM Q9NWZ3 26288698 501 FHSFSFYELKNVTNNFDERPISVGGNKMGEGFGVVYKGYVNNTTVAVKKLAEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4ztl C 2.39 BS01 4S1 C 1 M192 Y262 M265 P266 G268 A315 L318 S328 D329 M29 Y91 M94 P95 G97 A144 L147 S157 D158 D311 K313 A315 N316 D329 T351 D140 K142 A144 N145 D158 T176 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=1.2uM IC50=1193000nM Q9NWZ3 26288698 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 4ztl D 2.39 BS01 4S1 D 1 M192 G193 G195 A211 Y262 Y264 M265 G268 A315 L318 D329 M29 G30 G32 A47 Y94 Y96 M97 G100 A147 L150 D161 D311 K313 A315 N316 D329 T351 D143 K145 A147 N148 D161 T179 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 ic50=1.2uM IC50=1193000nM Q9NWZ3 26288698 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGFGVVYKGYVNNTTVAVKKLAATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS