4zom A 2.27 BS01 4Q3 A 1 W317 C320 H323 M365 F378 E379 F388 L391 C393 I397 I400 F401 H479 W53 C56 H59 M101 F114 E115 F124 L127 C129 I133 I136 F137 H215 ? 0003677,0004879,0005634,0006355 ic50=3nM -logKd/Ki=8.52, IC50=3nM EC50=10.0nM, IC50=4.9nM P51449 26048789 501 ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQ 4zom B 2.27 BS01 4Q3 B 1 C320 H323 M365 F378 F388 L391 C393 L396 I400 F401 H479 C56 H59 M101 F114 F124 L127 C129 L132 I136 F137 H215 ? 0003677,0004879,0005634,0006355 ic50=3nM EC50=10.0nM, IC50=4.9nM P51449 26048789 501 ASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIF 4zom C 2.27 BS01 4Q3 C 1 W317 C320 H323 F378 E379 F388 C393 L396 I397 I400 F401 H479 W50 C53 H56 F111 E112 F121 C126 L129 I130 I133 F134 H212 ? 0003677,0004879,0005634,0006355 ic50=3nM EC50=10.0nM, IC50=4.9nM P51449 26048789 501 TEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIF 4zom D 2.27 BS01 4Q3 D 1 C320 H323 F378 E379 F388 L391 C393 I397 F401 H479 C55 H58 F113 E114 F123 L126 C128 I132 F136 H214 ? 0003677,0004879,0005634,0006355 ic50=3nM EC50=10.0nM, IC50=4.9nM P51449 26048789 501 SLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHV