4zjj A 2.2 BS01 4OR A 1 M301 I312 E315 M319 N322 I327 V328 F379 N383 H387 L405 T406 M53 I60 E63 M67 N70 I75 V76 F127 N131 H135 L153 T154 D389 K391 D393 N394 D407 T427 D137 K139 D141 N142 D155 T168 2.7.11.1 0004672,0005524,0006468 Kd=9.9nM -logKd/Ki=8.00, Kd=9.9nM IC50=18nM, Kd=9.9nM Q13153 26191365 601 SDEEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLQKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKE 4zjj B 2.2 BS01 4OR B 1 E315 M319 I327 V328 F379 N383 H387 L405 T406 E60 M64 I72 V73 F124 N128 H132 L150 T151 D389 K391 D393 N394 D407 T427 D134 K136 D138 N139 D152 T165 2.7.11.1 0004672,0005524,0006468 Kd=9.9nM IC50=18nM, Kd=9.9nM Q13153 26191365 601 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIKQMNLKELIINEILVMRENKNPNIVNYLDSYLVGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQITTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKE 4zjj C 2.2 BS01 4OR C 1 E315 M319 N322 I327 V328 M344 F379 L380 N383 H387 L405 T406 D407 E60 M64 N67 I72 V73 M87 F122 L123 N126 H130 L148 T149 D150 D389 K391 D393 N394 D407 T427 D132 K134 D136 N137 D150 T163 2.7.11.1 0004672,0005524,0006468 Kd=9.9nM IC50=18nM, Kd=9.9nM Q13153 26191365 601 EEILEKLRSIVSVGDPKKKYTRFEKIGQGASGTVYTAMDVAQEVAIKQMNLQKKELIINEILVMRENKNPNIVNYLDSYLVELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGEQSKRSTMVGTPYWMAPEVVTAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEATK 4zjj D 2.2 BS01 4OR D 1 M301 E315 M319 N322 I327 V328 M344 F379 N383 H387 L405 T406 D407 F410 M43 E54 M58 N61 I66 V67 M81 F116 N120 H124 L142 T143 D144 F147 D389 K391 D393 N394 D407 P416 T427 D126 K128 D130 N131 D144 P149 T160 2.7.11.1 0004672,0005524,0006468 Kd=9.9nM IC50=18nM, Kd=9.9nM Q13153 26191365 601 EILEKLRSIVSVKKKYTRFEKIGQGASGTVYTAMDVEVAIKQMNLPKKELIINEILVMRENKNPNIVNYLDSYGDELWVVMEYLAGGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRALYLIATNGTPELQNPEKLSAIFRDFLNRCLEMDVEKRGSAKELLQHQFLKIAKPLSSLTPLIAAAKEAT