4z9l A 2.1 BS01 ANP A 1 G73 R107 S193 T226 Y229 E255 I261 G29 R63 S149 T172 Y175 E201 I207 D189 K191 N194 D207 T226 D145 K147 N150 D163 T172 2.7.11.24 0004672,0004707,0005524,0006468 P53779 12954329 501 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLSFMMVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFDSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPHTIEEWKELIYKEVMN 4z9l A 2.1 BS02 880 A 1 I70 V78 A91 I92 K93 I124 L144 M146 M149 A151 Q155 S193 N194 L206 I26 V34 A47 I48 K49 I80 L100 M102 M105 A107 Q111 S149 N150 L162 D189 K191 N194 D207 T226 D145 K147 N150 D163 T172 2.7.11.24 0004672,0004707,0005524,0006468 ic50=1.6nM -logKd/Ki=8.80, IC50=1.6nM IC50=1.6nM P53779 12954329 502 DNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLSFMMVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFDSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPHTIEEWKELIYKEVMN