4yz9 A 2.463 BS01 4K7 A 1 A581 K599 C605 A609 E612 V613 I626 L679 H686 D711 A20 K38 C44 A48 E51 V52 I65 L118 H125 D150 D688 K690 N693 D711 T734 D127 K129 N132 D150 T156 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 Ki=200nM -logKd/Ki=7.70, IC50=20nM O75460 26438213 1001 SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCGTEGWIAPEMLENPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHE 4yz9 B 2.463 BS01 4K7 B 1 K599 A609 E612 H686 R687 D711 K37 A47 E50 H124 R125 D149 D688 K690 N693 D711 D126 K128 N131 D149 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 Ki=200nM O75460 26438213 1001 VVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQKDFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCEGWIAPEMLSNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFH 4yz9 C 2.463 BS01 4K7 C 1 K599 A609 E612 V613 L616 I626 H686 D711 K38 A48 E51 V52 L55 I65 H123 D148 D688 K690 N693 D711 T734 D125 K127 N130 D148 T153 2.7.11.1,3.1.26.- 0004521,0004540,0004672,0004674,0005524,0006397,0006468,0030968 Ki=200nM O75460 26438213 1001 SVVIVGKISFCPKDVLGHGAEGTIVYRGMFDNRDVAVKRILPECFSFADREVQLLRESDEHPNVIRYFCTEKDRQFQYIAIELCAATLQEYVEQFAHLGLEPITLLQQTTSGLAHLHSLNIVHRDLKPHNILISMPNAHGKIKAMISDFGLCTEGWIAPEMLSNPTYTVDIFSAGCVFYYVISEGSHPFGKSLQRQANILLGACSLDCLHPEKHEDVIARELIEKMIAMDPQKRPSAKHVLKHPFFWSLEKQLQFFQDVSDRIEKESLDGPIVKQLERGGRAVVKMDWRENITVPLQTDLRKFRTYKGGSVRDLLRAMRNKKHHYRELPAEVRETLGSLPDDFVCYFTSRFPHLLAHTYRAMELCSHERLFQPYYFHE