4yxd A 3.0 BS01 FAD A 1 G26 A27 G28 T49 K50 L51 S56 H57 T58 A61 G63 G64 Y177 F178 A179 A213 T214 G215 T225 D233 L264 H365 Y366 G397 E398 R409 A412 S414 L415 L418 G17 A18 G19 T40 K41 L42 S47 H48 T49 A52 G54 G55 Y168 F169 A170 A204 T205 G206 T216 D224 L255 H356 Y357 G388 E389 R400 A403 S405 L406 L409 F131 Q252 H254 L264 E267 R270 R298 H365 Y366 R409 F122 Q243 H245 L255 E258 R261 R289 H356 Y357 R400 1.3.5.1 0005515,0005739,0005743,0006099,0006121,0008177,0009055,0016491,0016627,0022900,0045273,0050660 Q0QF01 26198225 700 STQYPVVDHEFDAVVVGAGGAGLRAAFGLSEAGFNTACVTKLFPTRSHTVAAQGGINAALGNMEEDNWRWHFYDTVKGSDWLGDQDAIHYMTEQAPASVVELENYGMPFSRTEDGKIYQRAFGGQSLKFGKGGQAHRCCCVADRTGHSLLHTLYGRSLRYDTSYFVEYFALDLLMENGECRGVIALCIEDGSIHRIRARNTVVATGGYGRTYFSCTSAHTSTGDGTAMVTRAGLPCQDLEFVQFHPTGIYGAGCLITEGCRGEGGILINSQGERFMERYAPVAKDLASRDVVSRSMTLEIREGRGCGPEKDHVYLQLHHLPPEQLAVRLPGISETAMIFAGVDVTKEPIPVLPTVHYNMGGIPTNYKGQVLRHVNGQDQVVPGLYACGEAACASVHGANRLGANSLLDLVVFGRACALSIAESCRPGDKVPSIKPNAGEESVMNLDKLRFANGTIRTSELRLSMQKSMQSHAAVFRVGSVLQEGCEKILRLYGDLQHLKTFDRGMVWNTDLVETLELQNLMLCALQTIYGAEARKESRGAHAREDFKERVDEYDYSKPIQGQQKKPFQEHWRKHTLSYVDVKTGKVSLEYRPVIDKTLNEADCATVPPAIRSY 4yxd B 3.0 BS01 FES B 1 C65 R66 G68 C70 G71 C73 C85 C57 R58 G60 C62 G63 C65 C77 1.3.5.1 0005515,0005739,0005743,0006099,0006121,0008177,0009055,0009060,0016491,0022904,0031966,0045273,0046872,0048039,0051536,0051537,0051538,0051539 Q007T0 26198225 301 PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE 4yxd B 3.0 BS02 SF4 B 1 C158 I159 L160 C161 A162 C164 C225 P226 C150 I151 L152 C153 A154 C156 C217 P218 1.3.5.1 0005515,0005739,0005743,0006099,0006121,0008177,0009055,0009060,0016491,0022904,0031966,0045273,0046872,0048039,0051536,0051537,0051538,0051539 Q007T0 26198225 302 PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE 4yxd B 3.0 BS03 F3S B 1 C168 Y178 C215 H216 T217 M219 N220 C221 C160 Y170 C207 H208 T209 M211 N212 C213 1.3.5.1 0005515,0005739,0005743,0006099,0006121,0008177,0009055,0009060,0016491,0022904,0031966,0045273,0046872,0048039,0051536,0051537,0051538,0051539 Q007T0 26198225 303 PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE 4yxd B 3.0 BS04 FTN C 1 P169 W173 H216 P161 W165 H208 1.3.5.1 0005515,0005739,0005743,0006099,0006121,0008177,0009055,0009060,0016491,0022904,0031966,0045273,0046872,0048039,0051536,0051537,0051538,0051539 -logKd/Ki=4.34, IC50=45.9uM Q007T0 26198225 302 PRIKKFAIYRWDPDKTGDKPHMQTYEIDLNNCGPMVLDALIKIKNEIDSTLTFRRSCREGICGSCAMNINGGNTLACTRRIDTNLDKVSKIYPLPHMYVIKDLVPDLSNFYAQYKSIEPYLKKKDESQEGKQQYLQSIEEREKLDGLYECILCACCSTSCPSYWWNGDKYLGPAVLMQAYRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTGTCPKGLNPGKAIAEIKKMMATYKE 4yxd C 3.0 BS01 HEM C 1 R46 G49 L52 S53 H101 H108 R41 G44 L47 S48 H96 H103 ? 0005515,0005739,0005743,0006099,0006121,0009055,0016020,0020037,0045273,0046872 D0VWV4 26198225 301 TTAKEEMERFWNKNLGSNRPLSPHITIYRWSLPMAMSICHRGTGIALSAGVSLFGLSALLLPGNFESHLELVKSLCLGPTLIYTAKFGIVFPLMYHTWNGIRHLIWDLGKGLTIPQLTQSGVVVLILTVLSSVGLAAM 4yxd C 3.0 BS02 FTN C 1 I30 W35 M39 S42 R46 I25 W30 M34 S37 R41 ? 0005515,0005739,0005743,0006099,0006121,0009055,0016020,0020037,0045273,0046872 -logKd/Ki=4.34, IC50=45.9uM D0VWV4 26198225 302 TTAKEEMERFWNKNLGSNRPLSPHITIYRWSLPMAMSICHRGTGIALSAGVSLFGLSALLLPGNFESHLELVKSLCLGPTLIYTAKFGIVFPLMYHTWNGIRHLIWDLGKGLTIPQLTQSGVVVLILTVLSSVGLAAM 4yxd D 3.0 BS01 HEM C 1 L54 H79 G83 L20 H45 G49 ? 0005515,0005739,0005740,0005743,0006099,0006121,0016020,0020037,0045273,0046872,0048039 A5GZW8 26198225 301 SSKAASLHWTGERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGIGQVVTDYVRGDALQKVAKAGLLALSAFTFAGLCYFNYHDVGICKAVAMLWKL 4yxd D 3.0 BS02 FTN C 1 D90 Y91 D56 Y57 ? 0005515,0005739,0005740,0005743,0006099,0006121,0016020,0020037,0045273,0046872,0048039 -logKd/Ki=4.34, IC50=45.9uM A5GZW8 26198225 302 SSKAASLHWTGERVVSVLLLGLLPAAYLNPCSAMDYSLAAALTLHGHWGIGQVVTDYVRGDALQKVAKAGLLALSAFTFAGLCYFNYHDVGICKAVAMLWKL