4yve A 3.4 BS01 4KK A 1 G85 G88 E89 V90 A103 K105 L107 M153 M156 A215 D216 G80 G83 E84 V85 A98 K100 L102 M148 M151 A210 D211 D198 K200 N203 D216 T237 D193 K195 N198 D211 T232 2.7.11.1 0004672,0004674,0005524,0006468 -logKd/Ki=7.00, Ki=100nM Ki=100nM Q13464 26039570 501 SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEETFPIPKAFVGNQLPFVGFTYYSNRRY 4yve B 3.4 BS01 4KK B 1 G85 A86 G88 E89 V90 A103 K105 M156 L205 D216 F368 G81 A82 G84 E85 V86 A99 K101 M152 L201 D212 F364 D198 K200 N203 D216 T237 D194 K196 N199 D212 T233 2.7.11.1 0004672,0004674,0005524,0006468 Ki=100nM Q13464 26039570 501 MSFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYDLDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYADSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKNDQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEEETFPIPKAFVGNQLPFVGFTYYSN