4yv2 A 2.17 BS01 S4M A 1 Q40 L59 Q64 H74 G95 D98 D118 I119 G150 D168 Q36 L55 Q60 H70 G91 D94 D114 I115 G146 D164 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv2 A 2.17 BS02 4K3 B 2 M24 W53 I63 T236 M20 W49 I59 T220 2.5.1.16 0003824,0004766,0006596,0016740 -logKd/Ki=7.29, IC50=0.051uM Q4DA73 26327378 303 ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv2 B 2.17 BS01 S4M B 1 Q40 L59 Q64 H74 G95 D98 D118 I119 G150 D168 T169 Q31 L50 Q55 H65 G86 D89 D109 I110 G141 D159 T160 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv2 B 2.17 BS02 4K3 B 1 M24 S25 L26 W53 I63 M15 S16 L17 W44 I54 2.5.1.16 0003824,0004766,0006596,0016740 -logKd/Ki=7.29, IC50=0.051uM Q4DA73 26327378 302 GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN