4yv1 A 1.85 BS01 S4M A 1 Q40 L59 Q64 Y73 H74 G95 D98 D118 I119 D149 G150 D168 T169 T170 Q31 L50 Q55 Y64 H65 G86 D89 D109 I110 D140 G141 D159 T160 T161 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 A 1.85 BS02 4K2 B 1 M24 W53 T236 M15 W44 T215 2.5.1.16 0003824,0004766,0006596,0016740 -logKd/Ki=3.08, IC50=830uM Q4DA73 26327378 302 GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 B 1.85 BS01 S4M B 1 Q40 L59 Q64 H74 G95 D98 D118 I119 D149 G150 D168 T169 T170 P175 A176 L179 Q36 L55 Q60 H70 G91 D94 D114 I115 D145 G146 D164 T165 T166 P171 A172 L175 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTDPAGPASKLFAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 B 1.85 BS02 4K2 B 1 E14 W19 Q22 M24 P238 C239 E10 W15 Q18 M20 P232 C233 2.5.1.16 0003824,0004766,0006596,0016740 ic50=830uM -logKd/Ki=3.08, IC50=830uM Q4DA73 26327378 302 ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTDPAGPASKLFAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 C 1.85 BS01 S4M C 1 Q40 L59 Q64 Y73 H74 G95 D98 D118 I119 G150 D168 T169 T170 Q33 L52 Q57 Y66 H67 G88 D91 D111 I112 G143 D161 T162 T163 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 SGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 C 1.85 BS02 4K2 D 1 M24 W53 M17 W46 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 302 SGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 D 1.85 BS01 S4M D 1 Q40 L59 Q64 Y73 H74 G95 D98 D118 I119 D149 G150 D168 T169 P175 Q36 L55 Q60 Y69 H70 G91 D94 D114 I115 D145 G146 D164 T165 P171 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTDPAGPASKLFAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yv1 D 1.85 BS02 4K2 D 1 W19 Q22 M24 Y237 P238 C239 W15 Q18 M20 Y231 P232 C233 2.5.1.16 0003824,0004766,0006596,0016740 ic50=830uM Q4DA73 26327378 302 ELISGGWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTDPAGPASKLFAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN