4yuz A 1.97 BS01 S4M A 1 Q40 L59 Q64 H74 G95 D98 D118 I119 G150 D168 T169 T170 Q31 L50 Q55 H65 G86 D89 D109 I110 G141 D159 T160 T161 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz A 1.97 BS02 4JV B 1 Q22 P238 C239 Q13 P217 C218 2.5.1.16 0003824,0004766,0006596,0016740 -logKd/Ki=5.04, IC50=9.1uM Q4DA73 26327378 302 GWFREENDQWPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz B 1.97 BS01 S4M B 1 Q40 H74 G95 D98 D118 I119 G150 D168 T169 Q32 H66 G87 D90 D110 I111 G142 D160 T161 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 ELISGGWFREEPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz B 1.97 BS02 4JV B 1 E14 M24 S25 W53 T236 E10 M16 S17 W45 T218 2.5.1.16 0003824,0004766,0006596,0016740 ic50=9.1uM -logKd/Ki=5.04, IC50=9.1uM Q4DA73 26327378 302 ELISGGWFREEPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz C 1.97 BS01 S4M C 1 Q40 L59 Q64 Y73 H74 G95 D98 D118 I119 G150 D168 T169 T170 Q32 L51 Q56 Y65 H66 G87 D90 D110 I111 G142 D160 T161 T162 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 ISGGWFREENDPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz C 1.97 BS02 4JV D 1 E14 Q22 P238 C239 E8 Q14 P218 C219 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 302 ISGGWFREENDPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTTAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz D 1.97 BS01 S4M D 1 Q40 Q64 G95 D98 D118 I119 D168 T169 Q34 Q58 G89 D92 D112 I113 D162 T163 2.5.1.16 0003824,0004766,0006596,0016740 Q4DA73 26327378 301 ELISGGWFREENDPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN 4yuz D 1.97 BS02 4JV D 1 E14 M24 S25 L26 W53 P235 T236 E10 M18 S19 L20 W47 P218 T219 2.5.1.16 0003824,0004766,0006596,0016740 ic50=9.1uM Q4DA73 26327378 302 ELISGGWFREENDPGQAMSLRVEKVLYDAPTKFQHLTIFESDPKGPWGTVMALDGCIQVTDYDEFVYHEVLGHTSLCSHPKPERVLIIGGGDGGVLREVLRHGTVEHCDLVDIDGEVMEQSKQHFPQISRSLADPRATVRVGDGLAFVRQTPDNTYDVVIIDTGEAFYKDVLRILKPDGICCNQGESIWLDLELIEKMSRFIRETGFASVQYALMHVPTYPCGSIGTLVCSKKAGVDVTKPLRPVEDMPFAKDLKYYDSEMHKASFALPRFARHINN