4yo6 A 2.32 BS01 4GD A 1 M192 G193 V200 A211 Y262 Y264 M265 G268 S269 M30 G31 V38 A49 Y95 Y97 M98 G101 S102 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T181 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 -logKd/Ki=5.66, IC50=2.2uM IC50=2200nM Q9NWZ3 26101573 501 TRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLATTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4yo6 B 2.32 BS01 4GD B 1 M192 G193 V200 A211 Y262 Y264 M265 G268 S269 L318 M32 G33 V40 A51 Y89 Y91 M92 G95 S96 L145 D311 K313 A315 N316 D329 T351 D138 K140 A142 N143 D156 T172 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=2200nM Q9NWZ3 26101573 501 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4yo6 B 2.32 BS02 4GD D 2 W285 C289 D422 S425 M457 T458 A459 W112 C116 D243 S246 M278 T279 A280 D311 K313 A315 N316 D329 T351 D138 K140 A142 N143 D156 T172 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=2200nM Q9NWZ3 26101573 502 SDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4yo6 C 2.32 BS01 4GD C 1 M192 V200 A211 Y262 Y264 M265 G268 L318 M29 V37 A48 Y96 Y98 M99 G102 L152 D311 K313 A315 N316 D329 T351 D145 K147 A149 N150 D163 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=2200nM Q9NWZ3 26101573 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS 4yo6 D 2.32 BS01 4GD D 1 M192 G193 V200 A211 Y262 Y264 M265 G268 L318 M29 G30 V37 A48 Y95 Y97 M98 G101 L151 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=2200nM Q9NWZ3 26101573 501 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA 4yo6 D 2.32 BS02 4GD D 2 H166 F168 V205 N206 H3 F5 V42 N43 D311 K313 A315 N316 D329 T351 D144 K146 A148 N149 D162 T180 2.7.11.1 0000287,0004672,0004674,0005524,0006468,0007165 IC50=2200nM Q9NWZ3 26101573 502 RFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASETVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTA