4yfi A 2.7 BS01 4CW A 1 I469 V477 A488 K490 T539 Y541 I542 L595 D606 I29 V37 A48 K50 T92 Y94 I95 L148 D159 D588 N590 H592 N593 D606 N627 D141 N143 H145 N146 D159 N169 2.7.11.1 0004672,0005524,0006468 -logKd/Ki=6.30, IC50=500nM IC50=500nM, Kd=111nM Q59H18 26355916 801 EKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAADMDMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 4yfi B 2.7 BS01 4CW B 1 A488 T539 I542 L595 D606 A38 T82 I85 L138 D149 D588 N590 H592 N593 D606 N627 D131 N133 H135 N136 D149 N160 2.7.11.1 0004672,0005524,0006468 IC50=500nM, Kd=111nM Q59H18 26355916 801 GLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAADMDMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELM 4yfi C 2.7 BS01 4CW C 1 I469 V477 A488 K490 T539 Y541 I542 L595 D606 I29 V37 A48 K50 T92 Y94 I95 L148 D159 D588 N590 H592 N593 D606 N627 D141 N143 H145 N146 D159 N170 2.7.11.1 0004672,0005524,0006468 IC50=500nM, Kd=111nM Q59H18 26355916 801 EKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYRSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAADMDMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNI 4yfi D 2.7 BS01 4CW D 1 A488 T539 I542 L595 D606 A38 T81 I84 L137 D148 D588 N590 H592 N593 D606 N627 D130 N132 H134 N135 D148 N159 2.7.11.1 0004672,0005524,0006468 IC50=500nM, Kd=111nM Q59H18 26355916 801 GLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIKRYSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSGNLRWMAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAADMDMAYHHIRPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCNIELM