4y86 A 2.01 BS01 49D A 1 L420 L421 Y424 F441 A452 Q453 F456 L236 L237 Y240 F257 A268 Q269 F272 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 ic50=11nM IC50=6.00nM O76083 26316540 601 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4y86 A 2.01 BS02 ZN A 1 H256 H292 D293 D402 H72 H108 D109 D218 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 O76083 26316540 602 KYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4y86 B 2.01 BS01 49E B 1 M365 L420 Y424 F441 A452 Q453 F456 M185 L240 Y244 F261 A272 Q273 F276 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 ic50=58nM O76083 26316540 601 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK 4y86 B 2.01 BS02 ZN B 1 H256 H292 D293 D402 H76 H112 D113 D222 3.1.4.35 0004114,0004115,0004117,0005515,0005654,0005737,0005783,0005794,0005829,0005886,0007165,0008081,0010613,0016787,0019933,0032587,0042383,0042995,0043204,0046068,0046069,0046872,0047555,0048101,0048471,1900273,2000178 O76083 26316540 602 PTYPKYLLSPETIEALRKPTFDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPVTLRRWLFCVHDNYRNNPFHNFRHCFCVAQMMYSMVWLCSLQEKFSQTDILILMTAAICHDLDHPGYNNTYQINARTELAVRYNDISPLENHHCAVAFQILAEPECNIFSNIPPDGFKQIRQGMITLILATDMARHAEIMDSFKEKMENFDYSNEEHMTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAPFMDRDKVTKATAQIGFIKFVLIPMFETVTKLFPMVEEIMLQPLWESRDRYEELKRIDDAMKELQKK