4y83 A 2.89 BS01 49B A 1 W132 I144 R146 V152 A165 K167 M207 G210 G213 S214 E217 V260 D270 W49 I61 R63 V69 A82 K84 M124 G127 G130 S131 E134 V177 D187 D253 K255 N258 D270 T290 D170 K172 N175 D187 T207 2.7.11.25 0004672,0005524,0006468 -logKd/Ki=7.77, IC50=17nM P41279 25918157 401 LSSVRYGTVEDLLAFANHRPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRGAFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALN 4y83 B 2.89 BS01 49B B 1 W132 I144 R146 A165 K167 M207 G210 G213 S214 E217 V260 V269 W50 I62 R64 A81 K83 M123 G126 G129 S130 E133 V176 V185 D253 K255 N258 D270 T290 D169 K171 N174 D186 T206 2.7.11.25 0004672,0005524,0006468 P41279 25918157 401 LSSVRYGTVEDLLAFANHISPQESGILLNMVITPQNGRYQIDSDVLLIPWKLTYRNIGSDFIPRFGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMTEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPPSYLYIIHKQAPPLEDIADDCSPGMRELIEASLERNPNHRPRAADLLKHEALNP 4y83 C 2.89 BS01 49B C 1 W132 I144 R146 V152 A165 M207 E208 G210 G213 V269 D270 W46 I58 R60 V63 A76 M118 E119 G121 G124 V180 D181 D253 K255 N258 D270 T290 D164 K166 N169 D181 T200 2.7.11.25 0004672,0005524,0006468 P41279 25918157 401 SSVRYGTVEDLLAFANHPQESGILLNMVITPQNGRYQIDSDVLIPWKLTYRNIGSDFIPRGKVYLAQDIKTKKRMACKLIPVDQFKPSDVEIQACFRHENIAELYGAVLWGETVHLFMEAGEGGSVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKKVIHHDIKPSNIVFMSTKAVLVDFGLSVQMEDVYFPKDLRGTEIYMSPEVILCRGHSTKADIYSLGATLIHMQTGTPPWVKRYPYPSYLYIIHKQAPPLEDICSPGMRELIEASLERNPNHRPRAADLLKHEALN