4y30 A 2.1 BS01 SAH A 1 Y48 Y51 M60 R66 G90 A91 L96 E112 A113 P139 V140 E141 E155 M166 S169 Y10 Y13 M22 R28 G52 A53 L58 E74 A75 P101 V102 E103 E117 M128 S131 D63 E155 E164 H317 D25 E117 E126 H279 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26101569 401 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELQAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 4y30 A 2.1 BS02 49L A 1 Y47 Y51 V56 E59 M60 E155 W156 M157 Y159 E164 H317 Y9 Y13 V18 E21 M22 E117 W118 M119 Y121 E126 H279 D63 E155 E164 H317 D25 E117 E126 H279 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 ic50=10nM IC50=10.0nM Q96LA8 26101569 402 TKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELQAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 4y30 B 2.1 BS01 SAH B 1 Y51 M60 R66 G90 A91 L96 E112 A113 P139 V140 E141 E155 M166 S169 Y27 M36 R42 G66 A67 L72 E88 A89 P115 V116 E117 E131 M142 S145 D63 E155 E164 H317 D39 E131 E140 H293 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 Q96LA8 26101569 401 DGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELQAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED 4y30 B 2.1 BS02 49L B 1 R43 L46 Y51 E59 M60 E155 W156 M157 E164 H317 N349 R19 L22 Y27 E35 M36 E131 W132 M133 E140 H293 N325 D63 E155 E164 H317 D39 E131 E140 H293 2.1.1.319 0000122,0003682,0005515,0005634,0005654,0005730,0006281,0006284,0006325,0006338,0008168,0008469,0010821,0016274,0018216,0032259,0035241,0035242,0036211,0042054,0042393,0044020,0045652,0045892,0070611,0070612,0090398,0140938,1901796,2000059 ic50=10nM IC50=10.0nM Q96LA8 26101569 402 DGAEREAALERPRRTKRERDQLYYECYSDVSVHEEMIADRVRTDAYRLGILRNWAALRGKTVLDVGAGTGILSIFCAQAGARRVYAVEASAIWQQAREVVRFNGLEDRVHVLPGPVETVELPEQVDAIVSEWMGYGLLHESMLSSVLHARTKWLKEGGLLLPASAELFIAPISDQMLEWRLGFWSQVKQHYGVDMSCLEGFATRCLMGHSEIVVQGLSGEDVLARPQRFAQLELSRAGLEQELQAGVGGRFRCSCYGSAPMHGFAIWFQVTFPGGESEKPLVLSTSPFHPATHWKQALLYLNEPVQVEQDTDVSGEITLLPSRDNPRRLRVLLRYKVGDQEEKTKDFAMED